Risks of herbal medicinal products
Risks of herbal medicinal products
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DOI：
10.1002/pds.1014
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发表时间：
2004-11-01
影响因子：
2.6
通讯作者：
Ernst, E
中科院分区：
文献类型：
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作者：
Ernst, E
目的草药产品（FLMP）再次受到高度欢迎。他们目前的普及，使他们的安全性评估的迫切necessary.Method叙事审查使用examples only.Results成分的HMPs可以是有毒的，许多例子的肝，肾或其他器官损伤的记录。所有的HMP都含有一系列的抗肿瘤活性成分，HMP的使用者经常将联合收割机HMP与处方药结合使用。因此，草药与药物的相互作用是一种真实的可能性。在大多数国家，有害物质不受严格的管理和控制。因此，不可靠的质量可能是一个问题。特别是，当HMP被污染（例如重金属）或掺假（例如处方药）时，这会带来风险。医学文献中有许多关于所有这些情况的例子，本文中使用了一些例子来说明上述观点。由于这一领域是严重不足的研究，它是很少可能定义的大小problem.Conclusions它的结论是，广泛的概念HMPs本质上是安全的是天真的，在最坏的情况下是危险的。需要进行更多的研究，以尽量减少HMP可能对消费者健康造成的风险。版权所有（C）2004约翰威利父子有限公司。
Purpose Herbal medicinal products (FLMPs) are again highly popular. Their current popularity renders the assessment of their safety an urgent necessity.Method Narrative review using examples only.Results Constituents of HMPs can be toxic and numerous examples of liver, kidney or other organ damage are on record. All HMPs contain a range of pharmacologically active constituents, and users of HMPs often combine HMPs with prescribed drugs. Thus herb-drug interactions are a real possibility. In most countries, HMPs are not submitted to stringent regulation and control. Thus unreliable quality can be a problem. In particular, this poses a risk when HMPs are contaminated (e.g. with heavy metals) or adulterated (e.g. with prescription drugs). The medical literature holds numerous examples for all of these scenarios and some are used in this article to illustrate the above points. As this area is grossly under-researched, it is rarely possible to define the size of the problem.Conclusions It is concluded that the widespread notion of HMPs being inherently safe is naive at best and dangerous at worst. More research is required to minimise the risk HMPs may pose to consumers' health. Copyright (C) 2004 John Wiley Sons, Ltd.