Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study
Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study
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DOI：
10.1002/oby.22785
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发表时间：
2020-05-01
期刊：
影响因子：
6.9
通讯作者：
Mashek, Douglas G.
中科院分区：
文献类型：
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作者：
Chow, Lisa S.;Manoogian, Emily N. C.;Mashek, Douglas G.
目的：与有意识地限制能量摄入相比，限制进食窗口可能是治疗肥胖的一种选择。通过比较限时饮食（TRE）与无限制（非TRE）对照，假设TRE有助于减肥、改变身体成分并改善代谢指标。方法：参与者（17名女性和3名男性;平均值[SD]：45.5 [12.1]岁; BMI 34.1 [7.5] kg/m2），进食窗延长（15.4 [0.9]小时）随机分为TRE组（n=11：8小时窗口，窗口内无限制进食）与非TRE组（n=9：无限制进食），持续12周。体重、身体成分（双能X线吸收法）、血脂、血压、2小时口服葡萄糖耐量、2周连续血糖监测和2周体力活动在干预前和干预结束时测量（体动仪评估）。结果：TRE组显著减少了进食窗口TRE组（终末干预时间窗：9.9 [2.0] h）与非TRE组（终末干预时间窗：15.1 [1.1] h）比较，差异有统计学意义（P < 0.01）。与非TRE相比，TRE减少了进食次数、体重、瘦体重和内脏脂肪（均P = 0.05）。与干预前措施相比，TRE组减少了进食次数（-21.9% [30.1%]），并减少了体重（-3.7% [1.8%]）、脂肪量（-4% [2.9%]）、瘦体重（-3.0% [2.7%]）和内脏脂肪（-11.1% [13.4%]）（所有P = 0.05）。体力活动和代谢措施保持不变。结论：在随机试验的设置，TRE提出了一个简化的观点，减少体重的食物摄入量。
Objective: In contrast to intentionally restricting energy intake, restricting the eating window may be an option for treating obesity. By comparing time-restricted eating (TRE) with an unrestricted (non-TRE) control, it was hypothesized that TRE facilitates weight loss, alters body composition, and improves metabolic measures.Methods: Participants (17 women and 3 men; mean [SD]: 45.5 [12.1] years; BMI 34.1 [7.5] kg/m2) with a prolonged eating window (15.4 [0.9] hours) were randomized to TRE (n=11: 8-hour window, unrestricted eating within window) versus non-TRE (n=9: unrestricted eating) for 12 weeks. Weight, body composition (dual x-ray absorptiometry), lipids, blood pressure, 2-hour oral glucose tolerance, 2-week continuous glucose monitoring, and 2-week physical activity (actigraphy assessed) were measured during the pre- and end-intervention periods.Results: The TRE group significantly reduced the eating window (endintervention window: 9.9 [2.0] hours) compared with the non-TRE group (end-intervention window: 15.1 [1.1] hours) (P < 0.01). Compared with non-TRE, TRE decreased the number of eating occasions, weight, lean mass, and visceral fat (all P = 0.05). Compared with preintervention measures, the TRE group reduced the number of eating occasions (-21.9% [30.1%]) and reduced weight (-3.7% [1.8%]), fat mass (-4% [2.9%]), lean mass (-3.0% [2.7%]), and visceral fat (-11.1% [13.4%]) (all P = 0.05). Physical activity and metabolic measures remained unchanged.Conclusions: In the setting of a randomized trial, TRE presents a simplified view of food intake that reduces weight.