Fabrication of selenium-deposited and chitosan-coated titania nanotubes with anticancer and antibacterial properties
Fabrication of selenium-deposited and chitosan-coated titania nanotubes with anticancer and antibacterial properties
复制标题
具有抗癌和抗菌特性的硒沉积和壳聚糖涂覆的二氧化钛纳米管的制备
DOI：
10.1016/j.colsurfb.2012.10.022
复制
发表时间：
2013-03-01
影响因子：
5.8
通讯作者：
Tang, Liling
中科院分区：
文献类型：
--
作者：
Chen, Xiuyong;Cai, Kaiyong;Tang, Liling
为了开发具有抗癌和抗菌性能的钛材料，在钛基体上制备了TiO 2纳米管阵列作为沉积硒的纳米储库，然后用壳聚糖层覆盖。采用电沉积法在TiO 2纳米管中沉积硒。采用场发射扫描电子显微镜（FE-SEM）、能谱仪（EDS）和接触角测量仪分别对基底的物理性能（表面形貌、化学组成和润湿性）进行表征。观察健康成骨细胞和癌成骨细胞在基质上的体外生长行为。硒沉积和壳聚糖涂层的二氧化钛纳米管衬底（二氧化钛纳米管-硒-Chi）表现出巨大的潜力，促进健康的成骨细胞的增殖和抑制癌性成骨细胞的生长。同时，TiO 2纳米管-Se-Chi基质显示出21天的硒持续释放。以大肠杆菌（Escherichia coli，E.大肠杆菌）。结果表明，TiO 2纳米管-Se-Chi复合载体具有较好的长期抗菌性能。本研究的方法为制备具有潜在临床应用价值的抗癌和抗菌钛基植入物提供了一种替代方法。(c)2012爱思唯尔有限公司版权所有。
To exploit titanium materials with anticancer and antibacterial properties, TiO2 nanotubes arrays as nanoreservoirs for deposition of selenium were generated onto titanium substrates and then covered with chitosan layer. The deposition of selenium in TiO2 nanotubes was performed with electrodeposition. The physical properties (surface morphologies, chemical compositions and wettability) of the substrates were characterized by field-emission scanning electron microscopy (FE-SEM) equipped with energy dispersive X-ray spectroscopy (EDS) and contact angle measurement, respectively. The growth behaviors of both healthy osteoblasts and cancerous osteoblasts on the substrates were investigated in vitro. The selenium-deposited and chitosan-coated TiO2 nanotubes substrates (TiO2 nanotubes-Se-Chi) demonstrated great potential for promoting the proliferation of healthy osteoblasts and inhibiting the growth of cancerous osteoblasts. Meanwhile, the TiO2 nanotubes-Se-Chi substrates displayed a sustained release of selenium for 21 days. The antibacterial properties of the prepared substrates were evaluated with Escherichia coli (E. coli). The result showed that TiO2 nanotubes-Se-Chi substrates had long term antibacterial capacity. The approach in this study provides an alternative to fabricate anticancer and antibacterial titanium-based implants for potential clinical application. (c) 2012 Elsevier B.V. All rights reserved.