Evaluation of the Choroidal Thickness Using High-Penetration Optical Coherence Tomography With Long Wavelength in Highly Myopic Normal-Tension Glaucoma
Evaluation of the Choroidal Thickness Using High-Penetration Optical Coherence Tomography With Long Wavelength in Highly Myopic Normal-Tension Glaucoma
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DOI：
10.1016/j.ajo.2011.05.037
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发表时间：
2012-01-01
影响因子：
4.2
通讯作者：
Nishida, Kohji
中科院分区：
文献类型：
--
作者：
Usui, Shinichi;Ikuno, Yasushi;Nishida, Kohji
目的：对高度近视正常眼压性青光眼(NTG)进行长波光学相干断层扫描(OCT)，评价脉络膜厚度。设计：横断面回顾性研究。方法：单位：机构。研究对象为年龄在45岁以下、无其他眼部疾病、屈光度在6~-12度之间、眼轴大于26.5 mm的NTG患者8例12眼，与健康志愿者相匹配的12眼。干预：用原型高穿透性OCT进行脉络膜成像，测量脉络膜厚度。主要观察指标：中心凹及5个部位的脉络膜厚度：视神经头中心上方、颞部、下方2 mm，距颞部上方2 mm、下方2 mm。结果：NTG组脉络膜厚度约为对照组的50%。正常对照组平均脉络膜厚度在中央凹(166比276微米，P；.001)、上(172比241微米，P；0.05)、颞上(161比244微米，P；0.01)、颞中(110比161微米，P；0.01)和颞下(115比159微米，P；0.05)明显变薄。逐步回归分析显示，黄斑中心凹脉络膜厚度是影响NTG发生的最主要因素(P<；.0001，R(2)=0.4)。结论：高度近视NTG患者的脉络膜厚度较对照组明显变薄，至少在某些特定部位是如此。脉络膜变薄与高度近视性NTG有关，可作为诊断近视性NTG的有用指标。(《眼科杂志》2012；153：10-16。(C)2012年由Elsevier Inc.保留所有权利。)
PURPOSE: To evaluate the choroidal thickness by high-penetration optical coherence tomography (OCT) using long wavelength in highly myopic normal-tension glaucoma (NTG).DESIGN: Cross-sectional retrospective study.METHODS: SETTINGS: Institutional. PARTICIPANTS Twelve eyes from 8 patients under 45 years old, diagnosed as NTG without any other ocular diseases, spherical equivalent refractive error between 6 and -12 diopters, and axial length greater than 26.5 mm; and 12 eyes of matched healthy volunteers. INTERVENTION: Choroid was imaged with prototype high-penetration OCT and its thickness was measured. MAIN OUTCOME MEASURES: Choroidal thickness at the fovea and 5 locations: 2 mm superior, temporal, and inferior to the center of the optic nerve head, and 2 mm superior (superotemporal) and 2 mm inferior (inferotemporal) to the temporal location.RESULTS: Overall, the choroidal thickness in the NTG group was approximately 50% that in controls. Mean choroidal thickness in the NTG group was significantly thinner in the control group at the fovea (166 vs 276 mu m, P < .001), superior (172 vs 241 mu m, P < 0.05), superotemporal (161 vs 244 mu m, P < .01), temporal (110 vs 161 P < .01), and inferotemporal (115 vs 159 mu m, P < .05) to the optic nerve head. Stepwise analysis disclosed that the fovea] choroidal thickness is the most influential factor on the occurrence of NTG (P < .0001, R(2) = 0.4).CONCLUSIONS: Choroidal thickness in highly myopic NTG is significantly thinner than in controls, at least in some specific locations. Choroidal thinning is somehow related with highly myopic NTG and may be a useful diagnostic parameter for myopic NTG. (Am J Ophthalmol 2012;153:10-16. (C) 2012 by Elsevier Inc. All rights reserved.)