The virome in early life and childhood and development of islet autoimmunity and type 1 diabetes: A systematic review and meta-analysis of observational studies.
The virome in early life and childhood and development of islet autoimmunity and type 1 diabetes: A systematic review and meta-analysis of observational studies.
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早期生命和儿童时期的病毒体以及胰岛自身免疫和1型糖尿病的发展：观察性研究的系统回顾和荟萃分析。
DOI：
10.1002/rmv.2209
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发表时间：
2021-09
影响因子：
11.1
通讯作者：
Kim KW
中科院分区：
文献类型：
--
作者：
Faulkner CL;Luo YX;Isaacs S;Rawlinson WD;Craig ME;Kim KW
根据大量的流行病学和实验证据，病毒被认为是胰岛自身免疫(IA)和1型糖尿病(T1D)的主要候选触发因素。最近的研究利用元基因组下一代测序(MNGS)研究了所有病毒(病毒组)与IA/T1D之间的关联。在没有语言限制的情况下，对Medline和EMBASE(发表于2000-2020年6月)的人类观察性研究进行了系统的回顾和荟萃分析，分析了早期生命病毒与IA/T1D的发展之间的当前联系。纳入标准如下：对患有IA/T1D的18岁≤儿童的临床标本进行MNGS检测的队列和病例对照研究。采用美国国家卫生与医学研究委员会证据水平量表和纽卡斯尔-渥太华量表进行研究评价。使用随机效应模型进行暴露于特定病毒的Meta分析，并使用优势比(OR)和95%可信区间(CI)来衡量关联强度。符合条件的研究(1个病例对照，9个嵌套病例对照)包括1425名参与者(695例，730名对照)，并检查了IA(n=1,023)或T1D(n=1,402)。Meta分析发现，IA与所有肠道病毒阳性的粪便样本数量(OR 1.14，95%CI 1.00-1.29，p=0.05；异质性χ2=91.51，p=0.68，i2=0.0%)、肠道病毒连续阳性(1.55，1.09-2.20，p=0.01；χ2χ=0.19，p=0.91，i 2=0.0%)和肠道病毒B特异性粪便标本数(1.2 0，1.0 1-1.4 2，p=0.0 4；p=0.0 3，p=0.86，i 2=0.0%)。到目前为止，病毒分析已经证明了肠道病毒和IA之间的关联，这可能具有临床意义。然而，为了进一步阐明早期病毒暴露和IA/T1D之间的关联，需要进行更大规模的前瞻性MNGS研究，并对怀孕期间进行更频繁的采样和随访。
Viruses are postulated as primary candidate triggers of islet autoimmunity (IA) and type 1 diabetes (T1D), based on considerable epidemiological and experimental evidence. Recent studies have investigated the association between all viruses (the ‘virome’) and IA/T1D using metagenomic next‐generation sequencing (mNGS). Current associations between the early life virome and the development of IA/T1D were analysed in a systematic review and meta‐analysis of human observational studies from Medline and EMBASE (published 2000–June 2020), without language restriction. Inclusion criteria were as follows: cohort and case–control studies examining the virome using mNGS in clinical specimens of children ≤18 years who developed IA/T1D. The National Health and Medical Research Council level of evidence scale and Newcastle–Ottawa scale were used for study appraisal. Meta‐analysis for exposure to specific viruses was performed using random‐effects models, and the strength of association was measured using odds ratios (ORs) and 95% confidence intervals (CIs). Eligible studies (one case–control, nine nested case–control) included 1,425 participants (695 cases, 730 controls) and examined IA (n = 1,023) or T1D (n = 402). Meta‐analysis identified small but significant associations between IA and number of stool samples positive for all enteroviruses (OR 1.14, 95% CI 1.00–1.29, p = 0.05; heterogeneity χ 2 = 1.51, p = 0.68, I 2 = 0%), consecutive positivity for enteroviruses (1.55, 1.09–2.20, p = 0.01; χ 2 = 0.19, p = 0.91, I 2 = 0%) and number of stool samples positive specifically for enterovirus B (1.20, 1.01–1.42, p = 0.04; χ 2 = 0.03, p = 0.86, I 2 = 0%). Virome analyses to date have demonstrated associations between enteroviruses and IA that may be clinically significant. However, larger prospective mNGS studies with more frequent sampling and follow‐up from pregnancy are required to further elucidate associations between early virus exposure and IA/T1D.
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影响因子：
8.2
作者：
Cinek, Ondrej;Stene, Lars C.;Ronningen, Kjersti S.
通讯作者：
Ronningen, Kjersti S.
影响因子：
3.4
作者：
Ekman, Ilse;Vuorinen, Tytti;Lempainen, Johanna
通讯作者：
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影响因子：
7.7
作者：
Bonifacio E;Warncke K;Winkler C;Wallner M;Ziegler AG
通讯作者：
Ziegler AG
影响因子：
4.6
作者：
Genoni A;Canducci F;Rossi A;Broccolo F;Chumakov K;Bono G;Salerno-Uriarte J;Salvatoni A;Pugliese A;Toniolo A
通讯作者：
Toniolo A
1型糖尿病的病毒触发因素：利弊。
影响因子：
7.7
作者：
Filippi, Christophe M.;von Herrath, Matthias G.
通讯作者：
von Herrath, Matthias G.