Myocardial rubidium-82 tissue kinetics assessed by dynamic positron emission tomography as a marker of myocardial cell membrane integrity and viability
Myocardial rubidium-82 tissue kinetics assessed by dynamic positron emission tomography as a marker of myocardial cell membrane integrity and viability
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DOI：
10.1161/01.cir.93.2.238
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发表时间：
1996-01-15
期刊：
影响因子：
37.8
通讯作者：
Schwaiger, M
中科院分区：
文献类型：
--
作者：
Dahl, J;Muzik, O;Schwaiger, M
背景：最近的报道表明，在注射示踪剂后的早期和后期，RB-82结合正电子发射断层扫描(PET)不仅可以作为心肌血流量的示踪剂，还可以作为细胞膜完整性的标志。本研究的目的是比较冠状动脉疾病患者心肌Rb-82动态显像和局部摄取18氟脱氧葡萄糖(FDG)的情况。方法和结果27例经冠状动脉造影证实的冠心病患者和5例低可能性冠状动脉疾病患者在静息状态下进行动态PET显像。这两个图像序列都作为半自动区域分析程序的输入数据。该程序生成了用Patlak方法评估的RB-82组织半衰期和FDG利用率的极图。心肌组织活性由静态RB-82和FDG图像直观确定。这些区域被归类为正常、缺血受损和疤痕组织。他们的坐标随后被复制到功能极地地图上进行进一步分析。在正常受试者中，RB-82的组织半衰期在整个左心室是均匀的(90+/-11秒)。在冠心病患者中，正常组织和瘢痕组织中RB-82半衰期的差异有非常显著意义(分别为95+/-10秒和57+/-15秒；P
Background Recent reports have demonstrated the clinical use of rubidium-82 chloride (Rb-82) in combination with positron emission tomography (PET) not only as a tracer of myocardial blood flow but also as a marker of cell membrane integrity using static imaging early and late after tracer injection. The purpose of this study was to compare myocardial Rb-82 kinetics assessed by dynamic PET imaging as a marker for tissue viability with regional fluorine-18 fluorodeoxyglucose (FDG) uptake in patients with coronary artery disease.Methods and Results Twenty-seven patients with angiographically proven coronary artery disease and 5 subjects with a low likelihood for coronary artery disease underwent dynamic PET imaging under resting conditions using Rb-82 and FDG. Both image sequences served as input data for a semiautomated regional analysis program. This program generated polar maps representing Rb-82 tissue half-life and FDG utilization assessed by Patlak's approach. Myocardial tissue viability was visually determined from static Rb-82 and FDG images. Regions were categorized as normal, ischemically compromised, and scar tissue. Their coordinates were subsequently copied to the functional polar maps for further analyses. In normal subjects, Rb-82 tissue half-life was homogeneous throughout the left ventricle (90+/-11 seconds). In coronary patients, differences between Rb-82 tissue half-lives in normal and scar tissue were highly significant (95+/-10 and 57+/-15 seconds, respectively; P