Prevalence of high fractional exhaled nitric oxide among US youth with asthma
Prevalence of high fractional exhaled nitric oxide among US youth with asthma
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DOI：
10.1002/ppul.23672
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发表时间：
2017-06-01
影响因子：
3.1
通讯作者：
Akinbami, Lara J.
中科院分区：
文献类型：
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作者：
Nguyen, Duong T.;Kit, Brian K.;Akinbami, Lara J.
研究背景高呼出气一氧化氮（FeNO）分数是哮喘控制不良的指标，并已被提议作为一种非侵入性评估工具来指导哮喘管理。对2012年全国健康与营养调查结果进行分析。根据美国胸科学会的指南，高FeNO定义为12-19岁> 50 ppb，6-11岁> 35 ppb。多变量logistic回归分析了高FeNO与年龄、性别、种族/西班牙裔、收入状况、体重状况、烟草烟雾暴露以及其他与哮喘控制相关的因素（近期使用吸入性皮质类固醇、近期呼吸道疾病、哮喘相关呼吸体征/症状和肺功能测定）之间的关系。非西班牙裔黑人中高FeNO的患病率较高（27%，P
BACKGROUNDHigh fractional exhaled nitric oxide (FeNO) is an indicator of poor asthma control and has been proposed as a non-invasive assessment tool to guide asthma management.OBJECTIVEWe aimed to describe the prevalence of and factors associated with high FeNO among US youth with asthma.METHODSData from 716 children and adolescents with asthma ages 6-19 years who participated in the 2007-2012 National Health and Nutrition Examination Survey were analyzed. Using American Thoracic Society guidelines, high FeNO was defined as >50ppb for ages 12-19 years and >35ppb for ages 6-11 years. Multivariate logistic regression examined associations between high FeNO and age, sex, race/Hispanic origin, income status, weight status, tobacco smoke exposure, and other factors associated with asthma control (recent use of inhaled corticosteroids, recent respiratory illness, asthma-related respiratory signs/symptoms, and spirometry).RESULTSAbout 16.5% of youth with asthma had high FeNO. The prevalence of high FeNO was higher among non-Hispanic black (27%, P