Association between preadmission low-density lipoprotein cholesterol concentration and risk of large intracerebral hemorrhage: Results from the Kailuan study.
Association between preadmission low-density lipoprotein cholesterol concentration and risk of large intracerebral hemorrhage: Results from the Kailuan study.
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DOI：
10.1002/jcla.24787
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发表时间：
2022-12
影响因子：
2.7
通讯作者：
中科院分区：
文献类型：
--
作者：
研究低密度脂蛋白胆固醇（LDL-C）浓度与脑出血（ICH）后大血肿体积风险之间的关系。本研究纳入了2006年至2020年期间因ICH住院的开滦研究（中国唐山）患者。对血脂浓度、血肿体积等临床特征进行回顾性分析。使用ABC/2方法在第一次可用的脑扫描上测量血肿体积。从ICH发生前的末次体格检查中获得LDL-C浓度。根据四分位数将LDL‐C浓度分为四组。使用Logistic回归评估LDL‐C浓度与≥30 ml大血肿体积风险之间的相关性。使用广义线性回归模型分析LDL‐C浓度与血肿体积之间的剂量-反应关系。共对836例ICH患者进行了评价。在多变量logistic回归分析中，与LDL_C的第二四分位数相比，LDL_C的第一四分位数具有显著更高的大血肿体积风险（OR 2.49 [95%CI 1.54-4.01]），并且LDL_C的较高四分位数与大血肿体积的较高几率无关。在广义线性回归模型中，LDL-C浓度与血肿体积之间相关性的校正β为9.46（95%置信区间2.87-16.04），而较高的LDL-C浓度与较大的血肿体积无关。本研究证实，ICH前低LDL‐C浓度与较大血肿体积的风险较高相关。在ICH发生前最后一次体格检查时获得LDL_C浓度。图片显示，脑出血后，LDL-C浓度<1.95 mmol/L的患者的血肿体积大于LDL-C浓度<2.51 mmol/L和> 1.95 mmol/L的患者。
To examine the association between low‐density lipoprotein cholesterol (LDL‐C) concentrations and the risk of a large hematoma volume after intracerebral hemorrhage (ICH). Patients from the Kailuan study (Tangshan, China) who were hospitalized with ICH during 2006 and 2020 were included in this study. The concentration of lipid concentrations, hematoma volume and other clinical characteristics were retrospectively collected and analyzed. Hematoma volumes were measured on the first available brain scan using the ABC/2 method. LDL‐C concentrations were obtained from the last physical examination before the occurrence of ICH. LDL‐C concentration was categorized into four groups in accordance with the quartiles. Logistic regression was used to assess the association between LDL‐C concentrations and the risk of a large hematoma volume of ≥30 ml. A generalized linear regression model was used to analyze the dose–response relationship between LDL‐C concentration and hematoma volume. A total of 836 patients with ICH were evaluated. In the Multivariate logistic regression, compared to the second quartile of LDL_C, the first quartile of LDL_C had a significantly higher risk of a large hematoma volume (OR 2.49 [95% CI 1.54–4.01]), and the higher quartile of LDL_C is not associated with higher odds of large hematoma volume. In the generalized linear regression model, the adjusted β for the association between LDL‐C concentration and hematoma volume was 9.46 (95% confidence interval 2.87–16.04), whereas higher LDL‐C concentration was not associated with a large hematoma volume. This study confirmed that low LDL‐C concentrations prior to ICH are associated with a higher risk of a large hematoma volume. The LDL_C concentrations were obtained from the last physical examination before the occurrence of ICH. The picture indicated that the patients with LDL‐C concentrations less than <1.95 mmol/L have a larger hematoma volume than the patients with LDL‐C concentrations less than 2.51 mmol/L and more than 1.95 mmol/L after intracerebral hemorrhage.
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影响因子：
8.3
作者：
Hemphill, JC;Bonovich, DC;Johnston, SC
通讯作者：
Johnston, SC
DOI：
10.1161/hypertensionaha.117.09479
发表时间：
2017-09
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Li W;Jin C;Vaidya A;Wu Y;Rexrode K;Zheng X;Gurol ME;Ma C;Wu S;Gao X
通讯作者：
Gao X
影响因子：
6.7
作者：
Hackeng, CM;Relou, IAM;Akkerman, JWN
通讯作者：
Akkerman, JWN
影响因子：
5.3
作者：
Chang, Jason J.;Katsanos, Aristeidis H.;Tsivgoulis, Georgios
通讯作者：
Tsivgoulis, Georgios
影响因子：
9.9
作者：
Davis, SM;Broderick, J;Steiner, T
通讯作者：
Steiner, T