Gastric histopathology, iron status and iron deficiency anemia in children with Helicobacter pylori infection
Gastric histopathology, iron status and iron deficiency anemia in children with Helicobacter pylori infection
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DOI：
10.1097/00005176-200402000-00008
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发表时间：
2004-02-01
影响因子：
2.9
通讯作者：
Pehlivanoglu, E
中科院分区：
文献类型：
--
作者：
Baysoy, G;Ertem, D;Pehlivanoglu, E
目的：幽门螺杆菌已被确定为成人和儿童胃炎和消化性溃疡疾病的主要原因。H.幽门螺杆菌感染也可能在一些胃肠道外疾病的发展中起作用，包括缺铁性贫血。本研究的目的是探讨H.幽门螺杆菌相关的胃生理学和组织学变化以及这些变化与儿童缺铁性贫血的关系。比较有和无H的患者的血液学参数、3天维生素C和铁消耗量、血清胃泌素水平和胃液抗坏血酸水平。幽门感染比较了H患者膳食维生素C和铁摄入量、血清胃泌素、胃液抗坏血酸含量和胃组织学。pylori感染与贫血的关系以及有H pylori感染但无贫血的患者。对H.结果：52例患者中28例检出H.幽门。31例患者患有缺铁性贫血。H.幽门螺杆菌感染与低血清铁水平有关。H.幽门螺杆菌性胃炎与胃液抗坏血酸水平降低有关。感染CagA阳性菌株与胃液中抗坏血酸的减少比感染CagA阴性菌株更大。H. pylori感染和贫血与非贫血的H.幽门。H. pylori感染者中，贫血组的泛红细胞增多率是无贫血组的2倍。幽门螺杆菌感染与胃液抗坏血酸浓度降低有关，这种作用在CagA阳性菌株患者中更为明显。在H. pylori感染伴贫血。
Objectives: Helicobacter pylori has been established as a major cause of gastritis and peptic ulcer disease in adults and children. H. pylori infection may also have a role in the development of some extragastrointestinal diseases, including iron deficiency anemia. The aim of this study is to investigate H. pylori-related changes in gastric physiology and histology and the relationship of these changes to iron deficiency anemia in children.Methods: Fifty-two patients with gastrointestinal complaints were studied. Hematologic parameters, 3-day vitamin C and iron consumption, serum gastrin levels, and gastric juice ascorbic acid levels were compared in patients with and without H. pylori infection. Dietary intake of vitamin C and iron, serum gastrin, gastric juice ascorbic acid content, and gastric histology were compared in patients with H. pylori infection and anemia and in patients with H pylori infection and no anemia. The CagA status of the H. pylori organisms was evaluated.Results: Twenty-eight of 52 patients had H. pylori. Thirty-one patients had iron deficiency anemia. H. pylori infection was associated with low serum iron levels. H. pylori gastritis was associated with a decrease in the gastric juice ascorbic acid level. Infection with CagA-positive strains was associated with a greater decrease in gastric juice ascorbic acid than infection with CagA-negative strains. However, the gastric juice ascorbic acid levels of patients with H. pylori and anemia were not different from those of non-anemic patients with H. pylori. Among patients with H. pylori infection, pangastritis was twice as common in those with anemia than in those without anemia.Conclusions: H. pylori infection was associated with a decrease in gastric juice ascorbic acid concentration, and this effect was more pronounced in patients with the CagA-positive strain. Pangastritis was more common in patients whose H. pylori.infection was accompanied by anemia.