Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases.
Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases.
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DOI：
10.1155/2015/620581
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发表时间：
2015
影响因子：
4.6
通讯作者：
Vandenbroucke RE
中科院分区：
文献类型：
--
作者：
Brkic M;Balusu S;Libert C;Vandenbroucke RE
神经退行性变是神经元细胞的慢性进行性损失，导致中枢神经系统（CNS）功能恶化。已经表明，在各种神经变性疾病中，神经炎症先于神经变性。基质金属蛋白酶（MMPs）是一种含锌内肽酶家族，在（神经）炎症中是必需的，并可能参与神经退行性变。尽管MMP对于生物体的生理发育和功能是不可或缺的，但由于它们在各种病理条件下也能够造成实质性损伤，因此它们通常被称为双刃剑。MMP活性受到严格控制，其失调导致多种病理。研究它们作为治疗靶点的潜在用途需要更好地了解它们对神经退行性疾病发展的贡献。本文综述了基质金属蛋白酶及其在神经退行性疾病中的作用：阿尔茨海默病（AD）、帕金森病（PD）、肌萎缩侧索硬化症（ALS）、亨廷顿病（HD）和多发性硬化症（MS）。我们还讨论了MMP抑制作为治疗神经退行性疾病的一种可能的治疗策略。
Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality. It has been shown that neuroinflammation precedes neurodegeneration in various neurodegenerative diseases. Matrix metalloproteinases (MMPs), a protein family of zinc-containing endopeptidases, are essential in (neuro)inflammation and might be involved in neurodegeneration. Although MMPs are indispensable for physiological development and functioning of the organism, they are often referred to as double-edged swords due to their ability to also inflict substantial damage in various pathological conditions. MMP activity is strictly controlled, and its dysregulation leads to a variety of pathologies. Investigation of their potential use as therapeutic targets requires a better understanding of their contributions to the development of neurodegenerative diseases. Here, we review MMPs and their roles in neurodegenerative diseases: Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and multiple sclerosis (MS). We also discuss MMP inhibition as a possible therapeutic strategy to treat neurodegenerative diseases.