Development and comorbidity of eczema, asthma and rhinitis to age 12-data from the BAMSE birth cohort
Development and comorbidity of eczema, asthma and rhinitis to age 12-data from the BAMSE birth cohort
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DOI：
10.1111/j.1398-9995.2012.02786.x
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发表时间：
2012-04-01
期刊：
影响因子：
12.4
通讯作者：
Wickman, M.
中科院分区：
文献类型：
--
作者：
Ballardini, N.;Kull, I.;Wickman, M.
背景：过敏相关疾病是一个公共卫生问题，但对儿童发育和并发症的了解很少。目的是研究湿疹，哮喘和鼻炎的发展与性别和父母的过敏，在一个以人口为基础的队列，在childhood.Methods：在1，2，4，8和12年，父母的问卷调查被用来获得过敏相关疾病的数据。从2916名儿童中获得了所有5次随访的完整数据。任何过敏相关疾病的风险与遗传和性别的比值比计算使用广义估计equations.Results：在12年，58%的儿童有湿疹，哮喘和/或鼻炎在某些时候。在整个研究中，所有三种疾病的疾病周转率都很高。合并症随着年龄的增长而增加，在12岁时，7.5%的儿童受到至少两种过敏相关疾病的影响。父母过敏与合并症增加和更持久的疾病相关，并增加了12年内发生任何过敏相关疾病的风险（校正OR 1.76; 95%CI 1.57-1.97）。男性在整个童年时期与风险增加有关。男孩和女孩没有不同的疾病的持续性，和合并症，差异是minor.Conclusions：过敏相关疾病可能会影响大多数儿童。湿疹、哮喘和鼻炎在整个儿童期动态发展，过敏性合并症很常见。这些发现表明，过敏相关疾病不应被视为孤立的实体，也不应被研究。
Background: Allergy-related diseases are a public health issue, but knowledge on development and comorbidity among children is scarce. The aim was to study the development of eczema, asthma and rhinitis in relation to sex and parental allergy, in a population-based cohort, during childhood.Methods: At 1, 2, 4, 8 and 12 years, parental questionnaires were used to obtain data on allergy-related diseases. Complete data for all five follow-up occasions were available from 2916 children. Odds ratios for the risk of any allergy-related disease in relation to heredity and sex were calculated using generalized estimating equations.Results: At 12 years, 58% of the children had had eczema, asthma and/or rhinitis at some time. Disease turnover was high for all three diseases throughout the study. Comorbidity increased with age, and at 12 years, 7.5% of all the children were affected by at least two allergy-related diseases. Parental allergy was associated with increased comorbidity and more persistent disease and increased the risk of having any allergy-related disease (adjusted OR 1.76; 95% CI 1.57-1.97) up to 12 years. Male sex was associated with an increased risk throughout childhood. Boys and girls did not differ in disease persistence, and for comorbidity, the differences were minor.Conclusions: Allergy-related diseases may affect a majority of children. Eczema, asthma and rhinitis develop dynamically throughout childhood, and allergic comorbidity is common. These findings indicate that allergy-related diseases should be neither seen nor studied as isolated entities.