Differences in semen characteristics between patients with testicular cancer and other malignancies using various cut-off values
Differences in semen characteristics between patients with testicular cancer and other malignancies using various cut-off values
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DOI：
10.1111/iju.13732
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发表时间：
2018-09-01
影响因子：
2.6
通讯作者：
Ohyama, Chikara
中科院分区：
文献类型：
--
作者：
Hamano, Itsuto;Hatakeyama, Shingo;Ohyama, Chikara
目的 使用不同的临界值比较睾丸癌和其他恶性肿瘤患者的精液参数，并评估精液参数与胞浆内单精子注射结果的相关性。方法我们回顾性调查了 1999 年 11 月至 2016 年 5 月在弘前大学医院冷冻保存精子的 117 例恶性肿瘤患者治疗前的精液参数。 睾丸癌和其他恶性肿瘤（非睾丸癌）、精原细胞瘤和非精原细胞瘤、I 期睾丸癌和 II/III 期睾丸癌患者之间的参数。在睾丸癌组和非睾丸癌组之间对世界卫生组织推荐的截止值和活动精子总数进行评估。对使用保存精子的患者进行胞浆内单精子注射的结果进行了评估。结果 在纳入的 111 名患者中，29 名 (26%) 患有睾丸癌，82 名 (74%) 患有非睾丸癌。睾丸癌患者的总精子浓度显着低于非睾丸癌患者。总精子浓度的临界值区分了睾丸癌（41％）和非睾丸癌（66％）患者之间超过临界值的患者比例。精原细胞瘤患者与非精原细胞瘤患者以及 I 期与 II/III 期睾丸癌患者之间的比较显示，精液参数没有显着差异。未观察到治疗前精液参数与胞浆内单精子注射结果之间的相关性。结论虽然睾丸癌患者的总精子浓度较低，但胞浆内单精子注射结果是可以接受的。有必要对睾丸癌患者的生育潜力进行进一步研究。
ObjectivesTo compare semen parameters between patients with testicular cancer and other malignancies using various cut-off values, and to evaluate the correlation between semen parameters and intracytoplasmic sperm injection outcomes.MethodsWe retrospectively investigated semen parameters before cancer treatment in 117 patients with malignancies who cryopreserved sperm at Hirosaki University Hospital between November 1999 and May 2016. We compared semen parameters between patients with testicular cancer and other malignancies (non-testicular cancer), seminoma and non-seminoma, and stage I testicular cancer and stage II/III testicular cancer. The assessment of cut-off values recommended by the World Health Organization and the total motile sperm count was carried out between the testicular cancer and non-testicular cancer groups. The intracytoplasmic sperm injection outcomes in those using preserved sperm were assessed.ResultsOf the 111 patients enrolled, 29 (26%) had testicular cancer and 82 (74%) had non-testicular cancer. Patients with testicular cancer showed significantly lower total sperm concentration than non-testicular cancer patients. The cut-off value of total sperm concentration distinguished the patient proportions exceeding the cut-off between patients with testicular cancer (41%) and non-testicular cancer (66%). The comparison between patients with seminoma versus non-seminoma and stage I versus stage II/III testicular cancer presented no significant differences in semen parameters. No correlation between pretreatment semen parameters and intracytoplasmic sperm injection outcomes was observed.ConclusionsAlthough testicular cancer patients show lower total sperm concentration, intracytoplasmic sperm injection outcomes are acceptable. Further studies on the fertility potential of testicular cancer patients are warranted.