Enantioselective Mannich Reaction of Glycine Iminoesters with N-Phosphinoyl Imines: A Bifunctional Approach
Enantioselective Mannich Reaction of Glycine Iminoesters with N-Phosphinoyl Imines: A Bifunctional Approach
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甘氨酸亚氨基酯与 N-膦酰亚胺的对映选择性曼尼希反应：一种双功能方法
DOI：
10.1021/acs.orglett.9b03223
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Zhang Min
中科院分区：
文献类型：
--
作者：
Zhang Changhui;Yang Jiao;Zhou Wenqiang;Tan Quiyuan;Yang Zhao;He Ling;Zhang Min
建立了甘氨酸亚氨基酯与正膦酰亚胺不对称Mannich反应的双功能催化方法。通过金属催化和有机催化的结合，有效地构建了邻近的两个立体中心，以高产率提供了广泛的二氨基酯，并具有良好的对映和非对映选择性(高达>；99：1dr，99%ee)。
A bifunctional catalytic approach for the asymmetric Mannich reaction of glycine iminoesters withN-phosphinoyl imines has been developed. By the combination of metal catalysis and organocatalysis, the vicinal two stereogenic centers were efficiently constructed, affording a wide range ofsyn-diamino esters in high yields with excellent enantio- and diastereoselectivities (up to >99:1 dr, 99% ee).