Association between serum prolactin levels and insulin resistance in non-diabetic men.
Association between serum prolactin levels and insulin resistance in non-diabetic men.
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DOI：
10.1371/journal.pone.0175204
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Nakaji S
中科院分区：
文献类型：
--
作者：
Daimon M;Kamba A;Murakami H;Mizushiri S;Osonoi S;Yamaichi M;Matsuki K;Sato E;Tanabe J;Takayasu S;Matsuhashi Y;Yanagimachi M;Terui K;Kageyama K;Tokuda I;Takahashi I;Nakaji S
催乳素（PRL）在多种生理功能中发挥作用。虽然实验研究表明，PRL对2型糖尿病既有有益的作用，也有不利的作用，但高泌乳素血症受试者的临床结果表明对葡萄糖代谢有不利影响。然而，PRL在人体生理范围内的作用存在争议。一项基于人群的研究，纳入了2014年Iwaki研究的370名日本男性（年龄52.0 ± 14.8岁）。在这项横断面研究中，使用多变量回归分析检查了血清催乳素水平与代表生理环境中葡萄糖代谢的稳态模型评估（HOMA）指数之间的关联。虽然单变量线性回归分析显示血清PRL水平与HOMA指数之间存在显著相关性，但多因素调整后与HOMA-R（胰岛素分泌）的相关性不显著，而与HOMA-R（胰岛素抵抗）的相关性仍然显著（P = 0.084，p = 0.035）。非线性回归分析显示，回归曲线在血清PRL水平12.4 ng/mL处具有峰值，并且血清PRL水平与低于峰值的HOMA-R呈正相关（P = 0.119，p = 0.004）。在生理范围内较高的血清PRL水平似乎与男性的胰岛素抵抗有关。
Prolactin (PRL) has roles in various physiological functions. Although experimental studies showed that PRL has both beneficial and adverse effects on type 2 diabetes mellitus, clinical findings in subjects with hyperprolactinemia indicate adverse effects on glucose metabolism. However, effects of PRL within the physiological range in human are controversial. A population-based study of 370 Japanese men enrolled in the 2014 Iwaki study (aged 52.0 ± 14.8 years). In this cross-sectional study, associations between serum PRL levels and homeostatic model assessment (HOMA) indices representing glucose metabolism in a physiological setting were examined using multivariable regression analysis. Although univariate linear regression analyses showed significant associations between serum PRL levels and HOMA indices, adjustment with multiple factors made the association with HOMA-ß (insulin secretion) insignificant, while those with HOMA-R (insulin resistance) remained significant (ß = 0.084, p = 0.035). Non-linear regression analyses showed a regression curve with a peak at serum PRL level, 12.4 ng/mL and a positive association of serum PRL level with HOMA-R below the peak (ß = 0.119, p = 0.004). Higher serum PRL levels within the physiological range seem to be associated with insulin resistance in men.