Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals.
Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals.
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DOI：
10.7554/elife.33891
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发表时间：
2018-06-06
期刊：
影响因子：
7.7
通讯作者：
Sanes DH
中科院分区：
文献类型：
--
作者：
Yao JD;Sanes DH
发育过程中的感觉剥夺会导致中枢神经系统功能的终生变化，这与知觉障碍有关。然而，由于在任务执行过程中缺乏同步测量，神经缺陷和行为缺陷之间的关系是不确定的。因此，我们从发育传导性听力损失沙土鼠的听觉皮质神经元进行遥测记录，因为它们在执行一项听觉任务时，检测到幅度的快速波动。这些数据被与每个动物的听觉脑干时间处理的测量进行了比较。我们发现，发育性HL会降低行为表现，但不会改变脑干的时间加工。然而，对神经和行为处理的同时评估显示，知觉缺陷与皮质种群代码的退化有关，这可以用更大的试验对试验反应的变异性来解释。我们的发现表明，早期听力损失的知觉限制可以用听觉皮质的编码缺陷来最好地解释。
Sensory deprivation during development induces lifelong changes to central nervous system function that are associated with perceptual impairments. However, the relationship between neural and behavioral deficits is uncertain due to a lack of simultaneous measurements during task performance. Therefore, we telemetrically recorded from auditory cortex neurons in gerbils reared with developmental conductive hearing loss as they performed an auditory task in which rapid fluctuations in amplitude are detected. These data were compared to a measure of auditory brainstem temporal processing from each animal. We found that developmental HL diminished behavioral performance, but did not alter brainstem temporal processing. However, the simultaneous assessment of neural and behavioral processing revealed that perceptual deficits were associated with a degraded cortical population code that could be explained by greater trial-to-trial response variability. Our findings suggest that the perceptual limitations that attend early hearing loss are best explained by an encoding deficit in auditory cortex.