Cancer risk in adulthood from early life exposure to parents' smoking.
Cancer risk in adulthood from early life exposure to parents' smoking.
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童年时期接触父母吸烟导致成年后罹患癌症的风险。
DOI：
10.2105/ajph.75.5.487
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发表时间：
1985
影响因子：
12.7
通讯作者：
J. P. Browder
中科院分区：
文献类型：
--
作者：
D. Sandler;R. Everson;A. Wilcox;J. P. Browder
我们从438例癌症病例和470例对照中获得了父母吸烟的数据，以调查成年后患癌症的风险是否与胎盘移植或儿童时期接触香烟有关。癌症病例在确诊时年龄在15至59岁之间。除皮肤基底细胞癌外的所有部位都包括在内。吸烟男性的后代患癌症的风险增加了50%。与父亲吸烟相关的风险增加不能用人口统计学因素、社会阶层或个人吸烟习惯来解释，也不限于已知的吸烟相关场所。与父亲吸烟相关的相对风险（RR）估计对于吸烟者、男性和非白人来说是最大的。与母亲吸烟有关的总体癌症风险仅略有增加。母亲和父亲的吸烟都与患造血癌的风险相关，并且存在剂量-反应关系。造血癌的风险比从父母一方吸烟时的1.7增加到父母双方都吸烟时的4.6。虽然它们应该被认为是暂时的，但研究结果表明，胎盘移植或儿童被动接触香烟烟雾会造成长期危害。
We obtained data on smoking by parents from 438 cancer cases and 470 controls to investigate whether cancer risk in adult life is related to transplacental or childhood exposure to cigarette smoke. Cancer cases were between ages 15 and 59 at time of diagnosis. All sites but basal cell cancer of the skin were included. Cancer risk was increased 50 per cent among offspring of men who smoked. Increased risk associated with father's smoking was not explained by demographic factors, social class, or individual smoking habits, and was not limited to known smoking related sites. Relative risk (RR) estimates associated with father's smoking tended to be greatest for smokers, males, and non-Whites. There was only a slight increase in overall cancer risk associated with maternal smoking. Mother's and father's smoking were both associated with risk for hematopoietic cancers, and a dose-response relationship was seen. The RR for hematopoietic cancers increased from 1.7 when one parent smoked to 4.6 when both parents smoked. Although they should be considered tentative, study findings suggest a long-term hazard from transplacental or childhood passive exposure to cigarette smoke.
母亲被动吸烟和胎儿血清硫氰酸盐水平。
影响因子：
9.8
作者：
Bottoms,SF;Kuhnert,BR;Kuhnert,PM;Reese,AL
通讯作者：
Reese,AL
影响因子：
4.7
作者：
Grufferman,S;Delzell,ES;Maile,MC;Michalopoulos,G
通讯作者：
Michalopoulos,G
DOI：
--
发表时间：
1982
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Grufferman,S;Wang,HH;DeLong,ER;Kimm,SY;Delzell,ES;Falletta,JM
通讯作者：
Falletta,JM