SOCIAL CONFRONTATION STRESS IN AGGRESSIVE FISH IS ASSOCIATED WITH AN ENDOGENOUS OPIOID-MEDIATED SUPPRESSION OF PROLIFERATIVE RESPONSE TO MITOGENS AND NONSPECIFIC CYTOTOXICITY
SOCIAL CONFRONTATION STRESS IN AGGRESSIVE FISH IS ASSOCIATED WITH AN ENDOGENOUS OPIOID-MEDIATED SUPPRESSION OF PROLIFERATIVE RESPONSE TO MITOGENS AND NONSPECIFIC CYTOTOXICITY
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DOI：
10.1016/0889-1591(89)90038-x
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发表时间：
1989-01-01
影响因子：
15.1
通讯作者：
WEINER H
中科院分区：
文献类型：
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作者：
FAISAL M;CHIAPPELLI F;WEINER H
我们之前已经表明，攻击性鱼类（例如罗非鱼）之间的社会对抗会抑制从属鱼类的几种免疫学参数——非特异性细胞毒性和丝裂原.sbd.刺激前肾白细胞.sbd.的增殖。通过使用阿片拮抗剂纳曲酮，我们现在间接证明这种免疫抑制部分是由内源性阿片系统介导的。有证据表明纳曲酮介导的免疫抑制逆转可能仅限于细胞毒性和 T 细胞谱系群体。对脂多糖的增殖反应不受纳曲酮的影响。我们的数据还表明，来自从属（免疫抑制）鱼类的血清对正常鱼类具有免疫抑制作用。sbd。这种效应可以通过纳曲酮逆转。这些结果支持了最低等脊椎动物鱼类的神经内分泌和免疫系统之间的联系。
We have previously shown that social confrontation between aggressive fish (e.g., Tilapia) produces a suppression of several immunological parameters-nonspecific cytotoxicity and mitogen.sbd.stimulated proliferation in pronephric leukocytes.sbd.in the subordinate fish. By using the opioid antagonist, naltrexone, we now demonstrate indirectly that this immunosuppression is in part mediated by the endogenous opioid system. Evidence is presented that naltrexone-mediated reversal of immunosuppression may be limited to the populations of the cytotoxic and T-cell lineages. The proliferation response to lipopolysaccharide is unaffected by naltrexone. Our data also demonstrate that serum from subordinate (immunosuppressed) fish is immunosuppressive in a normal fish.sbd.an effect that can be reversed by naltrexone. These results support a link between the neuroendocrine and immune systems in fish, the lowest vertebrate.