PATHOLOGICAL AND CLINICAL FINDINGS TO PREDICT TUMOR EXTENT OF NONPALPABLE (STAGE-T1C) PROSTATE-CANCER
PATHOLOGICAL AND CLINICAL FINDINGS TO PREDICT TUMOR EXTENT OF NONPALPABLE (STAGE-T1C) PROSTATE-CANCER
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DOI：
10.1001/jama.271.5.368
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发表时间：
1994-02-02
影响因子：
120.7
通讯作者：
BRENDLER, CB
中科院分区：
文献类型：
--
作者：
EPSTEIN, JI;WALSH, PC;BRENDLER, CB
目标。我们检查了接受根治性前列腺切除术的临床阶段T1c疾病男性患者的术前临床和病理参数，并将这些发现与手术标本中疾病的病理程度相关联，试图确定可能具有生物学意义不明显的肿瘤患者的亚群，这些患者可能无需立即治疗即可随访。设计和患者。157例连续接受根治性前列腺切除术的临床分期为T1c的患者，与64例接受类似治疗的临床分期为T1a的癌症（经尿道前列腺切除术发现的偶发微小癌症）和439例临床分期为T2（可触及）的癌症进行比较。主要结果测量。-病理分期、分级和边缘；肿瘤体积;肿瘤定位。- 16%的肿瘤无关紧要(
Objectives.-We examined preoperative clinical and pathologic parameters in men with clinical stage T1c disease who underwent radical prostatectomy and correlated these findings with the pathologic extent of disease in the surgical specimen in an attempt to identify a subset of patients with potentially biologically insignificant tumor who might be followed up without immediate treatment.Design and Patients.-A case series of 157 consecutive men who underwent radical prostatectomy for clinical stage T1c disease compared with 64 similarly treated clinical stage T1a cancers (incidental minimal cancers found on transurethral resection of prostate) and 439 clinical stage T2 (palpable) cancers.Main Outcome Measures.-Pathologic stage, grade, and margins; tumor volume; and tumor location.Results.-Sixteen percent of tumors were insignificant (