Arterial Spin-Labeling to Discriminate Pediatric Cervicofacial Soft-Tissue Vascular Anomalies
Arterial Spin-Labeling to Discriminate Pediatric Cervicofacial Soft-Tissue Vascular Anomalies
复制标题
DOI：
10.3174/ajnr.a5065
复制
发表时间：
2017-03-01
影响因子：
3.5
通讯作者：
Brunelle, F.
中科院分区：
文献类型：
--
作者：
Boulouis, G.;Dangouloff-Ros, V.;Brunelle, F.
背景和目的：区分颈面部血管病变的主要亚型对于适当的治疗至关重要。我们研究的目的是评估性能的MR成像动脉自旋标记灌注序列在区分小儿cervicofacial软组织vascular anomalies.MATERIALS AND METHODS：我们进行了一项回顾性分析的数据，从前瞻性维护的注册表，包括儿科患者在第三儿科中心之间的2012年1月和2014年1月。我们纳入了最终诊断为软组织血管异常和MR成像（包括就诊时的动脉自旋标记序列）的儿科患者。我们使用并行螺旋3D伪连续动脉自旋标记（1.5T磁体;螺旋矩阵，512 x 8 mm;标记后延迟，1025 ms）对病变灌注进行了分析，对临床数据不知情。用校准的病灶内ROI记录病灶血流。病变亚型之间的灌注特征进行了比较与情绪中位数test.RESULTS：在840例患者筛选，46匹配的纳入标准，包括（中位年龄，1.45岁;四分位数范围，0.4-5.1岁; 27名女性）。血管瘤，包括婴儿血管瘤（n = 18例）和非退化型（n = 2）和快速退化型（n = 1）先天性类型，表现出明显的高灌注（中位流量，436 mL/min/100 g;四分位数范围，212.5-603 mL/min/100 g），显著高于淋巴管畸形（中位数，22.5 mL/min/100 g;四分位数范围，16-60 mL/min/100 g; P < .001）或静脉畸形（中位数，25 mL/min/100 g;四分位数范围，15-66.5 mL/min/100 g; P = 0.003）。磁共振成像动脉自旋标记是一个有价值的工具，评估软组织血管异常血流动力学和分类的主要病变亚型。
BACKGROUND AND PURPOSE: Differentiating major subtypes of cervicofacial vascular lesions is crucial for appropriate management. The aim of our study was to evaluate the performance of an MR imaging arterial spin-labeling perfusion sequence in discriminating pediatric cervicofacial soft-tissue vascular anomalies.MATERIALS AND METHODS: We conducted a retrospective analysis of data from a prospectively maintained registry including pediatric patients at a tertiary pediatric center between January 2012 and January 2014. We included pediatric patients with a final diagnosis of soft-tissue vascular anomalies and an MR imaging, including an arterial spin-labeling sequence at presentation. We performed an analysis of lesion perfusion, blinded to clinical data, by using concurrent spiral 3D pseudocontinuous arterial spin-labeling (1.5T magnet; spiral matrix, 512 x 8 mm; postlabeling delay, 1025 ms). Lesional flow was recorded with calibrated intralesional ROIs. Perfusion characteristics were compared among lesion subtypes with the Mood Median test.RESULTS: Among 840 patients screened, 46 matched the inclusion criteria and were included (median age, 1.45 years; interquartile range, 0.4-5.1 years; 27 females). Hemangiomas, including infantile hemangiomas (n = 18 patients) and noninvoluting (n = 2) and rapidly involuting (n = 1) congenital types, demonstrated marked hyperperfusion (median flow, 436 mL/min/100 g; interquartile range, 212.5-603 mL/min/100 g), significantly higher than that of lymphatic malformations (median, 22.5 mL/min/100 g; interquartile range, 16-60 mL/min/100 g; P < .001) or venous malformations (median, 25 mL/min/100 g; interquartile range, 15-66.5 mL/min/100 g; P = .003).CONCLUSIONS: MR imaging arterial spin-labeling is a valuable tool for the assessment of soft-tissue vascular anomaly hemodynamics and for the classification of major lesion subtypes.