Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities.
Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities.
复制标题
Heliotropiumides A 和 B，是从夏威夷收集的 Heliotropium fertherianum 中含有 N-氨基甲酰基腐胺部分的新型酚酰胺及其生物活性。
DOI：
10.1016/j.bmcl.2017.09.021
复制
发表时间：
2017
影响因子：
2.7
通讯作者：
Cao,Shugeng
中科院分区：
文献类型：
--
作者：
Cai,You-Sheng;Sarotti,ArielM;Gündisch,Daniela;Kondratyuk,TamaraP;Pezzuto,JohnM;Turkson,James;Cao,Shugeng
Two new compounds heliotropiumides A (1) and B (2), phenolamides each with an uncommon carbamoyl putrescine moiety, were isolated from the seeds of a naturalized Hawaiian higher plant,Heliotropium foertherianumDiane & Hilger in the borage family, which is widely used for the treatment of ciguatera fish poisoning. The structures of compounds1and2were characterized based on MS spectroscopic and NMR analysis, and DP4+ calculations. The absolute configuration (AC) of compound1was determined by comparison of its optical rotation with those reported in literature. Compound2showed inhibition against NF-κB with an IC50value of 36 μM.
