Optical feedback-controlled scleral remodeling as a mechanism for myopic eye growth
Optical feedback-controlled scleral remodeling as a mechanism for myopic eye growth
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DOI：
10.1006/jtbi.1998.0727
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发表时间：
1998-08-21
影响因子：
2
通讯作者：
McDonnell, PJ
中科院分区：
文献类型：
--
作者：
Bryant, MR;McDonnell, PJ
近视的实验研究表明，施加在发育中的眼睛上的光学误差会刺激眼球的伸长，尽管轴向生长的机制尚不清楚。在这项研究中，提出了一个眼睛生长的数学模型，其中在巩膜重塑过程中，由于巩膜壳的弹性变形被纳入眼睛的零应力配置，因此眼球的膨胀发生。重塑的速度是由视网膜模糊和调节幅度决定的，这为单侧和双侧远视屈光不正补偿提供了反馈回路。树鼩是一种与灵长类动物有亲缘关系的小型哺乳动物，在树鼩身上模拟了正常的眼睛生长和实验性近视。该模型表明，实验性近视的眼伸长率可能通过调节巩膜壳内软组织重塑的速率来控制。(C) 1998学术出版社。
Experimental studies of myopia have demonstrated that optical errors imposed on a developing eye will stimulate elongation of the globe, although the mechanism of axial growth is not well understood. In this study, a mathematical model of eye growth is presented in which expansion of the globe occurs as the elastic deformations of the scleral shell are incorporated into the zero stress configuration of the eye during the scleral remodeling process. The rate of remodeling is determined by the retinal blur and the amplitude of accommodation, which provide feedback loops for both unilateral and bilateral hyperopic refractive error-compensation. Normal eye growth and experimental myopia are simulated in tree shrews, a small mammal related to primates. The model demonstrates that the rate of ocular elongation in experimental myopia may be controlled by regulating the rate of soft tissue remodeling in the scleral shell. (C) 1998 Academic Press.