The Immunogenetics of Morphea and Lichen Sclerosus
The Immunogenetics of Morphea and Lichen Sclerosus
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DOI：
10.1007/978-3-030-92616-8_7
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发表时间：
2022-01-01
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影响因子：
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通讯作者：
Beigi, Pooya Khan Mohammad
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文献类型：
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作者：
Beigi, Pooya Khan Mohammad
吗啡和萎缩性苔藓(LSA)是两种不同的免疫介导性疾病，主要表现为真皮纤维化和硬化症。这两种疾病有许多相似的临床和组织学特征，并倾向于同时发生。这两种疾病都被认为是由于对环境诱因的正常反应脱轨造成的。阳性家族史在LSA中比Morea更常见，但Morea的个体有更高的伴随和家族自身免疫的频率。这些发现提示遗传参与了对LSA和吗啡的易感性，从而为探索疾病遗传学提供了理论基础。本章全面回顾了这两种疾病的发病机制及其已知的遗传关联，包括人类白细胞抗原I类和II类基因。
Morphea and lichen sclerosis et atrophicus (LSA) are two distinct immune-mediated diseases with a dominant presentation of dermal fibrosis and sclerosis. The two diseases have many similar clinical and histological features and tend to co-occur. Both diseases are thought to result from a derailment of the normal response to environmental triggers. Positive family history is more common in LSA than morphea but individuals with morphea have a higher frequency of concomitant and familial autoimmunity. These findings hint at the involvement of inheritance in susceptibility to LSA and morphea and thus provide a rationale for exploring the disease genetics. This chapter contains a comprehensive review of the pathogenesis of the two diseases and their known genetic associations including HLA class I and II genes.