Brain imaging of pain: state of the art.
Brain imaging of pain: state of the art.
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DOI：
10.2147/jpr.s60433
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发表时间：
2016
影响因子：
2.7
通讯作者：
Jones AK
中科院分区：
文献类型：
--
作者：
Morton DL;Sandhu JS;Jones AK
疼痛是一种复杂的感觉和情感体验，它受到先前对疼痛的体验和预期的严重影响。在非侵入性人脑成像技术发展之前，我们对大脑在疼痛处理中的作用的理解仅限于死后研究的数据、大脑活动的直接记录、神经外科手术期间的患者体验和刺激以及疼痛的动物模型。神经影像学的进步弥补了大脑活动与疼痛主观体验之间的差距，使我们能够更好地了解与急性和慢性疼痛相关的大脑变化。此外，现在可以直接观察到对疼痛的认知影响，如注意力，预期和恐惧，从而可以解释疼痛心理调节的神经基础。使用功能性脑成像来测量内源性神经化学的变化，增加了我们对如何保持对疼痛的弹性和脆弱性的理解。
Pain is a complex sensory and emotional experience that is heavily influenced by prior experience and expectations of pain. Before the development of noninvasive human brain imaging, our grasp of the brain’s role in pain processing was limited to data from postmortem studies, direct recording of brain activity, patient experience and stimulation during neurosurgical procedures, and animal models of pain. Advances made in neuroimaging have bridged the gap between brain activity and the subjective experience of pain and allowed us to better understand the changes in the brain that are associated with both acute and chronic pain. Additionally, cognitive influences on pain such as attention, anticipation, and fear can now be directly observed, allowing for the interpretation of the neural basis of the psychological modulation of pain. The use of functional brain imaging to measure changes in endogenous neurochemistry has increased our understanding of how states of increased resilience and vulnerability to pain are maintained.