Abdominal obesity, sarcopenia, and osteoporosis are associated with frailty in men living with and without HIV.
Abdominal obesity, sarcopenia, and osteoporosis are associated with frailty in men living with and without HIV.
复制标题
腹部肥胖，肌肉减少症和骨质疏松症与患有和没有艾滋病毒的男性的男性脆弱有关。
DOI：
10.1097/qad.0000000000001829
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发表时间：
2018-06-19
期刊：
影响因子：
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通讯作者：
Erlandson KM
中科院分区：
文献类型：
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作者：
Hawkins KL;Zhang L;Ng DK;Althoff KN;Palella FJ Jr;Kingsley LA;Jacobson LP;Margolick JB;Lake JE;Brown TT;Erlandson KM
对感染艾滋病毒的老年人的虚弱和身体组成之间的关系知之甚少。我们试图描述携带和未携带艾滋病毒的成年男性之间的脆弱性和身体成分测量之间的关联。如果评估虚弱，则纳入多中心AIDS队列研究（MACS）骨强度子研究中的受试者（年龄50-69岁）（根据Fried表型）和身体组成（体重指数[BMI]、腰围[WC]、腹部内脏[VAT]和皮下[SAT]脂肪组织、肌肉减少和骨质减少/骨质疏松）。所有感染艾滋病毒的参与者都在接受抗逆转录病毒治疗。多变量多项逻辑回归模型被用来确定与身体组成的脆弱性的关联。共有399名男性，包括199名男性艾滋病毒感染者和200名男性无艾滋病毒感染者，两者的中位年龄均为60岁，组成了我们的研究人群。虚弱患病率为16.0%（感染艾滋病毒的男性）和8.0%（未感染艾滋病毒的男性）。HIV血清状态与2.43倍的虚弱几率相关（p=0.01）。较高的WC、VAT、肌肉减少症和股骨颈骨质疏松症与虚弱的几率增加相关（aOR分别为4.18、4.45、4.15和13.6，所有p <0.05）; BMI和SAT与此无关。这些指标均未显示出与HIV血清状态的虚弱的差异相关性（所有p>0.20）。高腹部肥胖和肌肉减少症与携带和不携带艾滋病毒的男性的虚弱有关。这些身体组成参数的评估可能有助于在临床环境中检测虚弱。
The relationships between frailty and body composition in older adults with HIV infection are poorly understood. We sought to describe associations between frailty and measures of body composition among adult men with HIV and without HIV Men with and without HIV (age 50–69 years) in the Multicenter AIDS Cohort Study (MACS) Bone Strength Substudy were included if evaluated for frailty (by Fried phenotype) and body composition (body mass index [BMI], waist circumference [WC], abdominal visceral [VAT] and subcutaneous [SAT] adipose tissue, sarcopenia, and osteopenia/osteoporosis). All participants with HIV infection were on antiretroviral therapy. Multivariate multinomial logistic regression models were used to determine associations of frailty with body composition. A total of 399 men, including 199 men with HIV and 200 men without HIV, both with median age 60 years, comprised our study population. Frailty prevalence was 16.0% (men with HIV) vs 8.0% (men without HIV). HIV serostatus was associated with a 2.43 times higher odds of frailty (p=0.01). Higher WC, VAT, sarcopenia, and femoral neck osteoporosis were associated with increased odds of frailty (aOR 4.18, 4.45, 4.15, and 13.6, respectively and all p <0.05); BMI and SAT were not. None of these measures presented a differential association with frailty by HIV serostatus (all p>0.20). Higher abdominal obesity and sarcopenia were associated with frailty among men with and without HIV. Assessment of these body composition parameters may help detect frailty in the clinical setting.