Depletion of collagen by losartan to improve tumor accumulation and therapeutic efficacy of photodynamic nanoplatforms
Depletion of collagen by losartan to improve tumor accumulation and therapeutic efficacy of photodynamic nanoplatforms
复制标题
氯沙坦消耗胶原蛋白以改善肿瘤积累和光动力纳米平台的治疗效果
DOI：
10.1007/s13346-018-00610-1
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发表时间：
2019-06-01
影响因子：
5.4
通讯作者：
Lu, Guangming
中科院分区：
文献类型：
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作者：
Tang, Yuxia;Liu, Ying;Lu, Guangming
纳米药物载体在肿瘤治疗中取得了很大的进展，但肿瘤细胞外致密的胶原蛋白极大地限制了药物的输送效率。在这项研究中，氯沙坦用于消耗肿瘤胶原蛋白，并提高氯6（Ce 6）负载的周期性介孔有机硅纳米平台（Ce 6-PMO）的递送效率和光动力学治疗乳腺癌的疗效。在体内用氯沙坦预处理后，与用盐水预处理的小鼠相比，肿瘤胶原I级分显著减少53%。重要的是，在用氯沙坦预处理小鼠后，分别通过瘤周和静脉内注射显著增强Ce 6-PMO纳米平台在肿瘤中的积累。此外，氯沙坦与Ce 6-PMO纳米平台的组合显示出最佳的治疗功效，并且测量到肿瘤体积的抑制率高达82%。总之，这项研究提供了一个非常有前途的协同策略，以提高肿瘤的纳米平台的光动力治疗效果。
Nanocarriers for drug delivery have made great progress in the treatment of cancer, but the dense extracellular collagen of tumors has greatly limited the efficiency of drug delivery. In this study, losartan is used to deplete tumor collagen and improve the delivery efficiency and photodynamic therapeutic efficacy of chlorine 6 (Ce6)-loaded periodic mesoporous organosilica nanoplatform (Ce6-PMO) for breast cancer. After pretreatment with losartan in vivo, the tumor collagen I fraction is significantly reduced by 53% compared to that of mice pretreated with saline. Importantly, the accumulation of the Ce6-PMO nanoplatforms in the tumor is remarkably enhanced via peritumoral and intravenous injection, respectively, after the mice are pretreated with losartan. Further, combination of losartan with the Ce6-PMO nanoplatforms shows the best therapeutic efficacy, and the suppression rate of tumor volume is measured up to 82%. Taken together, this study provides a very promising synergetic strategy to improve the tumor photodynamic treatment efficacy of nanoplatforms.