MATLYSTATINS, NEW INHIBITORS OF TYPE-IV COLLAGENASES FROM ACTINOMADURA-ATRAMENTARIA .4. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF MATLYSTATIN-B AND ITS STEREOISOMERS
MATLYSTATINS, NEW INHIBITORS OF TYPE-IV COLLAGENASES FROM ACTINOMADURA-ATRAMENTARIA .4. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF MATLYSTATIN-B AND ITS STEREOISOMERS
复制标题
DOI：
10.7164/antibiotics.47.1481
复制
发表时间：
1994-12-01
影响因子：
3.3
通讯作者：
SUGIMURA, Y
中科院分区：
文献类型：
--
作者：
TAMAKI, K;KURIHARA, S;SUGIMURA, Y
首次合成了matlystatin B (1a)，这是一种低分子量的IV型胶原酶抑制剂，其绝对构型得到了明确的确定。进一步合成了1a的10个立体异构体，并研究了每个立体异构体对92 kDa IV型胶原酶和其他金属蛋白酶的抑制作用。
The first total synthesis of matlystatin B (1a), a low molecular weight inhibitor of type IV collagenases, was accomplished, and its absolute configuration was unambiguously determined. Furthermore, ten stereoisomers of 1a were synthesized, and the inhibition of the 92 kDa type IV collagenase and of other metalloproteinases by each stereoisomer was investigated.