Macrophage-specific gene expression: Current paradigms and future challenges
Macrophage-specific gene expression: Current paradigms and future challenges
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DOI：
10.1007/bf02982713
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发表时间：
2002-07-01
影响因子：
2.1
通讯作者：
Gordon, S
中科院分区：
文献类型：
--
作者：
Greaves, DR;Gordon, S
单核吞噬细胞谱系的细胞包括巨噬细胞、小胶质细胞、破骨细胞和髓样树突细胞。这些细胞类型都来源于血液单核细胞，这是造血干细胞分化的产物。在这篇综述中，我们使用巨噬细胞表达基因的具体例子来说明潜在的调控策略，指导巨噬细胞特异性基因表达。我们选择的例子-人类c-fes基因。鼠spi-1（PU.1）基因，人RANTES启动子。和人CD 68基因-说明了巨噬细胞中组成型和诱导型基因表达的不同方面。在这一领域的未来工作的一个重要挑战将是确定在单核吞噬细胞从造血祖细胞分化过程中决定谱系决定的分子事件。另一个重要的目标将是了解巨噬细胞基因组如何协调表达，以响应生理，免疫和炎症刺激。更好地了解巨噬细胞基因表达可能会在基因治疗中找到应用。基因疫苗和新的抗病毒药物的开发。(C)2002年日本血液学会。
Cells of the mononuclear phagocyte lineage include macrophages, microglia, osteoclasts, and myeloid dendritic cells. These cell types are all derived from blood monocytes, which are the product of hematopoietic stem cell differentiation. In this review we use specific examples of macrophage-expressed genes to illustrate potential regulatory strategies for directing macrophage-specific gene expression. The examples we have chosen-the human c-fes gene. the murine spi-1 (PU.1) gene, the human RANTES promoter. and the human CD68 gene-illustrate different aspects of constitutive and inducible gene expression in macrophages. One important challenge for future work in this field will be to identify the molecular events that dictate lineage decisions during the differentiation of mononuclear phagocytes from hematopoietic progenitor cells. Another important goal will be to understand how groups of macrophage genes are coordinately expressed in response to physiological, immunological, and inflammatory stimuli. A better understanding of macrophage gene expression may find application in gene therapy. genetic vaccination, and the development of new antiinflammatory drugs. (C) 2002 The Japanese Society of Hematology.