Antiplatelet therapy in secondary stroke prevention--state of the art.

Antiplatelet therapy in secondary stroke prevention--state of the art.
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二级中风预防中的抗血小板治疗——最先进的。

DOI:
10.1111/j.1582-4934.2010.01163.x
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发表时间:
2010-11
影响因子:
5.3
通讯作者:
Weber R
Weber R
中科院分区:
医学2区
文献类型:
--
作者:
Diener HC;Weimar C;Weber R

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我们的目标是为读者提供一个概述,以及目前抗血小板治疗的二级中风预防的最新进展。作者手工搜索相关期刊,以汇编一份广泛但到目前为止还不全面的创新和临床相关研究的总结。阿司匹林、氯吡格雷和双嘧达莫联合阿司匹林是二级预防非心源性卒中或短暂性脑缺血发作的基石。一对一的比较显示,双嘧达莫加阿司匹林和氯吡格雷在预防中风复发方面没有差异。更有效的抗血小板药物或阿司匹林和氯吡格雷的联合使用可以预防更多的缺血事件,但也会导致更多的出血并发症。对于房颤患者的二级卒中预防,口服抗凝比阿司匹林或阿司匹林和氯吡格雷联合应用更有效。
Our objective is to provide the reader with an overview as well as an update on current antiplatelet therapy for secondary stroke prevention. Relevant journals were hand-searched by the authors to compile a broad but by far not comprehensive summary of innovative and clinically relevant studies. Aspirin, clopidogrel and the combination of dipyridamole plus aspirin are the cornerstone therapy in secondary prevention after non-cardio-embolic stroke or transient ischaemic attack. A head-to-head comparison showed no difference in the prevention of recurrent stroke between dipyridamole plus aspirin and clopidogrel. More potent antiplatelet drugs or the combination of aspirin and clopidogrel prevent more ischaemic events, but also lead to more bleeding complications. For secondary stroke prevention in patients with atrial fibrillation, oral anticoagulation is more effective than aspirin or the combination of aspirin and clopidogrel.
DOI: 10.1161/strokeaha.106.476648
发表时间: 2008-01-01
期刊: STROKE
影响因子: 8.3
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