Comparison of age of first drink and age of first intoxication as predictors of substance use and mental health problems in adulthood
Comparison of age of first drink and age of first intoxication as predictors of substance use and mental health problems in adulthood
复制标题
DOI：
10.1016/j.drugalcdep.2018.10.012
复制
发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Boden, Joseph M.
中科院分区：
文献类型：
--
作者：
Newton-Howes, Giles;Cook, Susan;Boden, Joseph M.
背景。关于首次饮酒年龄（AFD）的国际公共政策强调推迟AFD的长期利益。本研究旨在比较AFD与首次中毒年龄（AFI）作为成年期物质使用障碍和精神障碍结果的预测因子。方法：数据来自新西兰克赖斯特彻奇的纵向出生队列。参与者出生于1977年。分析样本范围从n = 1025（18岁）到n = 962（35岁）。AFD和AFI的测量是使用从11岁开始收集的父母和自我报告数据生成的。18-35岁的结局是酒精消耗量、DSM-IV酒精使用障碍（AUD）和AUD症状、重度抑郁、焦虑障碍以及尼古丁、大麻和其他非法药物依赖。儿童期测量的协变量因素包括家庭社会经济地位、家庭功能、父母与酒精相关的态度/行为以及个人因素。结果：AFD与AUD症状（p < 0.001）和尼古丁依赖（p < 0.05）之间存在显著的未经调整的相关性，但其他结局无显著相关性。AFI与所有结果显著相关（p < 0.05）。协变量调整后，AFD与结果之间的关联无统计学意义。相反，在调整后的模型中，AFI与所有AUD和物质使用障碍结果之间仍然存在统计学意义（p < 0.05）的关联，但与酒精消耗或精神障碍结果无关。结论：AFI比AFD更能预测成人药物使用障碍的预后。因此，旨在预防酒精长期危害的公共卫生和政策干预应侧重于AFI而不是AFD。
Background. International public policy on age of first alcoholic drink (AFD) has emphasised the long-term benefits of delaying AFD. This study aimed to compare AFD to age of first intoxication (AFI) as predictors of substance use disorder and mental disorder outcomes in adulthood.Methods: Data were obtained from a longitudinal birth cohort in Christchurch, New Zealand. Participants were born in 1977. Analysis samples ranged from n = 1025 (age 18) to n = 962 (age 35). Measures of AFD and AFI were generated using parental- and self-report data collected from age 11. Outcomes at age 18-35 were alcohol quantity consumed, DSM-IV alcohol use disorder (AUD) and AUD symptoms, major depression, anxiety disorder, and nicotine, cannabis, and other illicit drug dependence. Covariate factors measured during childhood included family socioeconomic status, family functioning, parental alcohol-related attitudes/behaviours, and individual factors.Results: There was a significant unadjusted association between AFD and symptoms of AUD (p < .001) and nicotine dependence (p < .05) but not other outcomes. AFI was significantly (p < .05) associated with all outcomes. After adjustment for covariates, the association between AFD and outcomes was not statistically significant. Conversely, in adjusted models, statistically significant (p < .05) associations remained between AFI and all AUD and substance use disorder outcomes but not alcohol consumption or mental disorder outcomes.Conclusions: AFI was a more robust predictor of adult substance use disorder outcomes than AFD. Public health and policy interventions aimed at prevention of long term harms from alcohol should therefore focus on AFI rather than AFD.