Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis
Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis
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DOI：
10.1136/bmj.324.7350.1361
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发表时间：
2002-06-08
影响因子：
--
通讯作者：
Bulpitt, CJ
中科院分区：
文献类型：
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作者：
D'Souza, AL;Rajkumar, C;Bulpitt, CJ
目的评价益生菌制剂防治抗生素相关性腹泻的疗效。结局数据（未发生腹泻的患者比例）进行分析、汇总和比较，以确定治疗组和对照组的优势比。通过检索1966年至2000年之间的Medline和科克伦图书馆确定的鉴定研究。益生菌的安慰剂对照试验。结果9项研究中有2项调查了益生菌对儿童的影响。四项试验使用酵母（布拉酵母），四项使用乳酸杆菌，一项使用产生乳酸的肠球菌菌株。三项试验使用了益生菌菌株的组合。在所有9项试验中，益生菌与抗生素联合使用，对照组接受安慰剂和抗生素。在预防抗生素相关腹泻方面，积极治疗优于安慰剂的优势比为0.39（95%置信区间为0.25至0.62; P
Objective To evaluate efficacy of probiotics in prevention and treatment of diarrhoea associated with the use of antibiotics.Design Meta-analysis; outcome data (proportion of patients not getting diarrhoea) were analysed, pooled, and compared to determine odds ratios in treated and control groups.Identification Studies identified by searching Medline between 1966 and 2000 and the Cochrane Library.Studies reviewed Nine randomised, double blind, placebo controlled trials of probiotics.Results Two of the nine studies investigated the effects of probiotics in children. Four trials used a yeast (Saccharomyces boulardii), four used lactobacilli, and one used a strain of enterococcus that produced lactic acid. Three trials used a combination of probiotic strains of bacteria. In all nine trials, the probiotics were given in combination with antibiotics and the control groups received placebo and antibiotics. The odds ratio in favour of active treatment over placebo in preventing diarrhoea associated with antibiotics was 0.39 (95% confidence interval 0.25 to 0.62; P