Social reward network connectivity differs between autistic and neurotypical youth during social interaction.
Social reward network connectivity differs between autistic and neurotypical youth during social interaction.
复制标题
在社交互动过程中，自闭症青少年和神经正常青少年的社会奖励网络连接有所不同。
DOI：
10.1101/2023.06.05.543807
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Redcay,Elizabeth
中科院分区：
文献类型：
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作者：
Xie,Hua;Moraczewski,Dustin;McNaughton,KathrynA;Warnell,KatherineR;Alkire,Diana;Merchant,JunaidS;Kirby,LauraA;Yarger,HeatherA;Redcay,Elizabeth
自闭症的一个核心特征是社交困难。非典型的社会动机提出了这些困难的基础。然而，先前的工作测试这一假设已经显示出混合的支持，并已在其理解自闭症的现实世界的社会互动过程的能力有限。我们试图解决这些局限性，通过扫描神经型和自闭症青年（n = 86）在基于文本的互惠社会互动，模仿一个“活”的聊天和eleclient社会奖励过程。我们专注于任务诱发的功能连接（FC）的区域负责更广泛的社会奖励回路内的动机奖励和心理化过程。我们发现，这些区域之间的任务诱发的FC显着调制的社会互动和社会互动奖励的接收。与神经正常的同龄人相比，自闭症青年在心智化网络中的核心区域表现出更大的任务诱发连接性（例如，后上级颞沟）和杏仁核（奖励网络中的关键节点）。此外，跨组，这些心智化和奖励区域之间的连接强度与自我报告的社会动机和社会奖励在扫描器任务呈负相关。我们的研究结果强调了FC在更广泛的社会奖励回路中的重要作用。具体而言，更大的上下文相关FC（即，社会参与和非社会参与之间的差异）可能表明在社会奖励期间增加的“神经努力”，并且与自闭症和神经型人群中社会动机的差异有关。
A core feature of autism is difficulties with social interaction. Atypical social motivation is proposed to underlie these difficulties. However, prior work testing this hypothesis has shown mixed support and has been limited in its ability to understand real-world social-interactive processes in autism. We attempted to address these limitations by scanning neurotypical and autistic youth (n = 86) during a text-based reciprocal social interaction that mimics a “live” chat and elicits social reward processes. We focused on task-evoked functional connectivity (FC) of regions responsible for motivational-reward and mentalizing processes within the broader social reward circuitry. We found that task-evoked FC between these regions was significantly modulated by social interaction and receipt of social-interactive reward. Compared to neurotypical peers, autistic youth showed significantly greater task-evoked connectivity of core regions in the mentalizing network (e.g., posterior superior temporal sulcus) and the amygdala, a key node in the reward network. Furthermore, across groups, the connectivity strength between these mentalizing and reward regions was negatively correlated with self-reported social motivation and social reward during the scanner task. Our results highlight an important role of FC within the broader social reward circuitry for social-interactive reward. Specifically, greater context-dependent FC (i.e., differences between social engagement and non-social engagement) may indicate an increased “neural effort” during social reward and relate to differences in social motivation within autistic and neurotypical populations.