Efficacy of milnacipran for glossodynia patients
Efficacy of milnacipran for glossodynia patients
复制标题
米那普仑治疗舌痛患者的疗效
DOI：
10.1080/13651500310000861
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发表时间：
2003
影响因子：
3
通讯作者：
A. Toyofuku
中科院分区：
文献类型：
--
作者：
A. Toyofuku
疼痛和抑郁被认为是由去甲肾上腺素能和肾上腺素能神经元水平的常见神经化学功能障碍引起的，抗抑郁药被用于治疗慢性疼痛。双作用三环类抗抑郁药在缓解疼痛方面比选择性5-羟色胺再摄取抑制剂更有效。舌痛是舌头的慢性疼痛和烧灼感，通常与抑郁症有关。患有舌痛的患者用最近在日本上市的5-羟色胺和去甲肾上腺素再摄取抑制剂米那普仑治疗。米那普仑被认为是有效的缓解慢性舌痛和良好的耐受性。
Pain and depression are thought to arise from a common neurochemical dysfunction at the level of noradrenergic and serotonergic neurons, and antidepressants are used to treat chronic pain. The dual action tricyclic antidepressants are more potent in relieving pain than the selective serotonin reuptake inhibitors. Glossodynia is chronic pain and burning sensation in the tongue often associated with depression. Patients suffering from glossodynia were treated with the serotonin and noradrenaline reuptake inhibitor, milnacipran, which has been recently launched in Japan. Milnacipran was found to be effective in the relief of the chronic glossodynia and well tolerated.