Relation of oral hairy leukoplakia to infection with the human immunodeficiency virus and the risk of developing AIDS.
Relation of oral hairy leukoplakia to infection with the human immunodeficiency virus and the risk of developing AIDS.
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口腔毛状白斑与人类免疫缺陷病毒感染以及患艾滋病风险的关系。
DOI：
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发表时间：
1987
影响因子：
6.4
通讯作者：
J. Levy
中科院分区：
文献类型：
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作者：
D. Greenspan;J. Greenspan;N. Hearst;L. Pan;M. Conant;D. Abrams;H. Hollander;J. Levy
我们调查了口腔毛状白斑（HL）与人类免疫缺陷病毒（HIV）感染和艾滋病的存在或发展的关系。在我们的诊所里看到的所有155例HL患者都是免疫抑制的同性恋男性。在从这一组未患艾滋病的患者中获得的101份血清样本中，有100份显示出艾滋病毒抗体。从28例受试患者中的22例外周血单核细胞中回收了HIV。免疫印迹法检测的大多数血清样品与病毒包膜和gag基因前体gp160和p55反应。在155名患者中，12名在诊断时患有艾滋病，另外43名患者在1至31个月内出现了这种综合征。生存分析显示，HL患者发生AIDS的概率在16个月时为48%，在31个月时为83%。我们的结论是，口服HL是高度预测艾滋病的发展。
We investigated the relation of oral hairy leukoplakia (HL) to human immunodeficiency virus (HIV) infection and to the presence or development of AIDS. All 155 patients with HL seen in our clinic were immunosuppressed homosexual men. Of 101 serum samples obtained from patients in this group who did not have AIDS, 100 showed antibodies to HIV. HIV was recovered from peripheral blood mononuclear cells of 22 of 28 patients tested. Most serum samples examined by immunoblot assay reacted with the viral envelope and gag gene precursors gp160 and p55. Of the 155 patients, 12 had AIDS at the time of diagnosis, and the syndrome developed in an additional 43 patients in one to 31 months. Survival analysis showed that the probability of AIDS developing in patients with HL was 48% by 16 months and 83% by 31 months. We conclude that oral HL is highly predictive of the development of AIDS.
影响因子：
158.5
作者：
KLEIN, RS;HARRIS, CA;FRIEDLAND, GH
通讯作者：
FRIEDLAND, GH
影响因子：
39.2
作者：
Walsh,C;Krigel,R;Lennette,E;Karpatkin,S
通讯作者：
Karpatkin,S