Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma
Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma
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DOI：
10.1038/sj.onc.1207832
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发表时间：
2005-01-06
期刊：
影响因子：
8
通讯作者：
Yasui, W
中科院分区：
文献类型：
--
作者：
Kondo, T;Oue, N;Yasui, W
PINX 1是一种可能的端粒酶抑制剂和假定的肿瘤抑制剂，其在包括胃癌（GC）在内的人类癌症中的表达尚未研究。我们采用定量逆转录-聚合酶链反应（RT-PCR）检测了73例胃癌组织中PINX 1的表达，并对其中的45例进行了微卫星标记D8 S277的PCR检测，以进一步研究其杂合性丢失（洛）。表达减少（肿瘤与正常比率
The expression of PINX1, a possible telomerase inhibitor and a putative tumor suppressor, has not been studied in human cancers, including gastric cancer (GC). We examined expression of PINX1 by quantitative reverse transcription (RT)-PCR in 73 cases of GC, and 45 of these cases were further studied for loss of heterozygosity (LOH) by PCR with microsatellite marker D8S277. Reduced expression (tumor vs normal ratio