Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health
Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health
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DOI：
10.1016/j.envres.2017.11.052
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发表时间：
2018-02-01
影响因子：
8.3
通讯作者：
Kishi, Reiko
中科院分区：
文献类型：
--
作者：
Minatoya, Machiko;Araki, Atsuko;Kishi, Reiko
双酚A和邻苯二甲酸盐广泛存在于人体尿液、血液、母乳和羊水中。双酚 A 和邻苯二甲酸盐都被认为在肥胖流行中发挥着作用。在胎儿发育过程中接触这些化学物质及其后果应该引起关注，因为它们可以穿过胎盘。因此，本研究旨在评估产前接触双酚 A 和邻苯二甲酸盐与脐带血代谢相关生物标志物之间的关联。在妊娠前三个月使用母体血清来确定产前双酚 A 和邻苯二甲酸盐的暴露情况。还测定了脐带血中代谢相关生物标志物的水平。对 365 名参与者应用线性回归模型，进行暴露和生物标志物评估，并根据母亲年龄、孕前体重指数、胎次、教育程度和孩子性别进行调整。双酚A水平与瘦素水平呈负相关（β=-0.06，95%置信区间[CI]：-0.11，-0.01），但与高分子量脂联素水平呈正相关，且具有边际显着性（β=0.03，95%CI：0.00，0.06）。邻苯二甲酸单异丁酯 (MiBP)、邻苯二甲酸单正丁酯 (MnBP)、邻苯二甲酸单 (2-乙基己基)酯 (MEHP) 以及代表 DEHP 暴露水平的 MEHP 和 MECPP 之和 (Sigma DEHPm) 水平与瘦素水平呈负相关（β = -0.14，95%CI：-0.27，-0.01；β = -0.12， 95%CI：-0.24，0.00，边际显着性；β=0.08，95%CI：-0.14，0.03；β=-0.09，95%CI：-0.16，-0.03。本研究提供了一些证据，表明产前接触双酚 A 和某些邻苯二甲酸盐可能会改变胎儿脂联素和瘦素水平。
Bisphenol A and phthalates are widely detected in human urine, blood, breast milk, and amniotic fluid. Both bisphenol A and phthalates have been suggested as playing a role in obesity epidemics. Exposure to these chemicals during fetal development, and its consequences should be concerning because they can cross the placenta. Thus, this study aimed to assess the association between prenatal exposure to bisphenol A and phthalates, and cord blood metabolic-related biomarkers. Maternal serum was used during the first trimester, to determine prenatal exposure to bisphenol A and phthalates. Levels of metabolic-related biomarkers in the cord blood were also determined. Linear regression models were applied to the 365 participants with both, exposure and biomarker assessments, adjusted for maternal age, pre-pregnancy body mass index, parity, education, and sex of the child. The level of bisphenol A was negatively associated with the leptin level (beta = -0.06, 95% confidence interval [CI]: -0.11, -0.01), but was positively associated with the high-molecular-weight adiponectin level, with marginal significance (beta = 0.03, 95%CI: 0.00, 0.06). The mono-isobutyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), mono-(2-ethylhexyl) phthalate (MEHP), and summation of MEHP and MECPP to represent DEHP exposure (Sigma DEHPm) levels were inversely associated with the leptin levels (beta = -0.14, 95%CI: -0.27, -0.01; beta = -0.12, 95%CI: -0.24, 0.00 with marginal significance; beta = 0.08, 95%CI: -0.14, 0.03; and beta = -0.09, 95%CI: -0.16, -0.03, respectively). The present study provided some evidence that prenatal exposure to bisphenol A and certain phthalates may modify fetal adiponectin and leptin levels.