A Concise Total Synthesis of Amphidinolide T2
A Concise Total Synthesis of Amphidinolide T2
复制标题
Amphidinolide T2 的简明全合成
DOI：
10.1002/chem.201001794
复制
发表时间：
2010-01-01
影响因子：
4.3
通讯作者：
Dai, Wei-Min
中科院分区：
文献类型：
--
作者：
Li, Huoming;Wu, Jinlong;Dai, Wei-Min
RCM+ AD= T2：在C16-亚甲基存在下，区域选择性闭环复分解（RCM）生成（12 E）-内环双键，再经Os催化的不对称双羟基化（AD）反应，经16步线性反应得到12，13-二醇中间体，总收率8.0%。
RCM+ AD= T2: In the presence of the C16-methylene group, regioselective ring-closing metathesis (RCM) formed the (12E)-endocyclic double bond, which underwent Os-catalyzed asymmetric dihydroxylation (AD) to give the desired 12, 13-diol intermediate required for the total synthesis of amphidinolide T2 in 16 linear steps in 8.0% overall yield.