The association of cerebrospinal fluid pressure with optic nerve head and macular vessel density
The association of cerebrospinal fluid pressure with optic nerve head and macular vessel density
复制标题
DOI：
10.1007/s11427-021-1984-5
复制
发表时间：
2021-10-29
影响因子：
9.1
通讯作者：
Wang, Ningli
中科院分区：
文献类型：
--
作者：
Liu, Xiangxiang;Khodeiry, Mohamed M.;Wang, Ningli
本研究旨在利用光学相干断层扫描血管造影术研究暂时性脑脊液压力（CSFP）降低对视神经乳头（ONH）和黄斑血管密度（VD）的影响。招募了44名诊断性腰椎穿刺和CSFP复位的成人的44只眼睛。32例健康志愿者32只眼为对照组。观察CSFP减容前后ONH和黄斑部VD的变化。结果显示，平均CSFP从（11.6 +/- 2.1）mmHg降至（8.2 +/- 3.4）mmHg（P0.05）。总之，黄斑血管密度降低与CSFP减少相关。CSFP减少后，黄斑区视网膜血管密度比视乳头周围区更敏感。
The present study aims to investigate the effect of temporary cerebrospinal fluid pressure (CSFP) reduction on optic nerve head (ONH) and macular vessel density (VD) using optical coherence tomography angiography. Forty-four eyes of 44 adults with diagnostic lumbar puncture and CSFP reduction were recruited. Thirty-two eyes of 32 healthy volunteers were controls. ONH and macular VD images were evaluated differences between baseline and after CSFP reduction. The results showed that the mean CSFP decreased from (11.6 +/- 2.1) mmHg to (8.2 +/- 3.4) mmHg (P0.05). In conclusion, macular vessel density decreased in association with CSFP reduction. Retinal vessel density in the macular region is more sensitive than that in peripapillary region after CSFP reduction.