Virulence profile of strains of Cryptococcus neoformans var. grubii evaluated by experimental infection in BALB/c mice and correlation with exoenzyme activity
Virulence profile of strains of Cryptococcus neoformans var. grubii evaluated by experimental infection in BALB/c mice and correlation with exoenzyme activity
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DOI：
10.1099/jmm.0.46206-0
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发表时间：
2006-02-01
影响因子：
3
通讯作者：
Paula, CR
中科院分区：
文献类型：
--
作者：
da Silva, EG;Baroni, FD;Paula, CR
目的评价新生隐球菌变异株的毒力特性。grubii，将62株该酵母菌接种BALB/c小鼠。结果发现，69%的菌株对小鼠的致死性显著更高，并且与其他31%的菌株相比，从更高百分比（60%）的器官中回收，而其他31%的菌株从35%的测试器官中回收。那些引起更高死亡率的菌株从中枢神经系统中的回收率（84%）也高于致命性较低的菌株（32%）。这一发现导致了对增强动物神经感染和死亡能力的因素的调查。本研究结果表明，环境菌株呈现不同程度的毒力。接种前后和小鼠组之间的外切酶生产的相关性表明，外切酶生产没有影响菌株之间的毒力差异。
To evaluate the virulence profile of strains of Cryptococcus neoformans var. grubii, 62 strains of this yeast were inoculated into BALB/c mice. It was found that 69% of the strains were significantly more lethal to the mice and were recovered from a higher percentage (60%) of the organs compared with the other 31% of the strains, which were recovered from 35% of organs tested. Those strains that provoked higher death rates were also recovered from the central nervous system at a higher rate (84%) than the less lethal strains (32%). This finding led to an investigation of the factors that enhanced the capacity for neurological infection and death of the animals. The results of this study suggested that environmental strains present different degrees of virulence. The correlation of exoenzyme production before and after inoculation and between the groups of mice indicated that exoenzyme production had no influence on differences in virulence among the strains studied.