Obesity and the metabolic syndrome in pediatric psoriasis
Obesity and the metabolic syndrome in pediatric psoriasis
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DOI：
10.1016/j.clindermatol.2014.12.006
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发表时间：
2015-05-01
影响因子：
2.7
通讯作者：
Shah, Kara N.
中科院分区：
文献类型：
--
作者：
Gutmark-Little, Iris;Shah, Kara N.
牛皮癣是一种常见的慢性炎症性皮肤病，通常在儿童时期发病。越来越多的证据表明，成年人的银屑病与肥胖、代谢综合征和相关的共病有关，包括胰岛素抵抗/2型糖尿病、血脂异常、高血压和心血管疾病。据推测，这种联系至少部分是由脂肪组织介导的全身性促炎状态引起的。最近的几项观察研究表明，患有牛皮癣的儿童和青少年超重和肥胖的风险可能会增加，代谢综合征的风险也会增加。这种关联引起了人们对患有银屑病的儿童和青少年的长期健康影响的关注，并表明在这一人群中需要更好地认识、评估和管理超重和肥胖患者以及相关的代谢性疾病。(C)2015 Elsevier Inc.保留所有权利。
Psoriasis is a common, chronic inflammatory dermatosis that often has its onset during childhood. There is increasing evidence that psoriasis in adults is associated with obesity, the metabolic syndrome, and associated comorbidities, including insulin resistance/type 2 diabetes, dyslipidemia, hypertension, and cardiovascular disease. This association is postulated to arise, at least in part, as a result of a systemic proinflammatory state that is mediated by adipose tissue. Several recent observational studies suggest that children and adolescents with psoriasis may be at increased risk of being overweight and obese as well as having an increased risk for features of the metabolic syndrome. Such an association raises concern with regards to the long-term health implications for children and adolescents with psoriasis and suggests that better awareness, evaluation, and management of overweight and obese patients and associated metabolic disease are warranted in this population. (C) 2015 Elsevier Inc. All rights reserved.