Mesoporous Silica Coated Single-Walled Carbon Nanotubes as a Multifunctional Light-Responsive Platform for Cancer Combination Therapy
Mesoporous Silica Coated Single-Walled Carbon Nanotubes as a Multifunctional Light-Responsive Platform for Cancer Combination Therapy
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介孔二氧化硅涂层单壁碳纳米管作为癌症联合治疗的多功能光响应平台
DOI：
10.1002/adfm.201403079
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发表时间：
2015-01-21
影响因子：
19
通讯作者：
Liu, Zhuang
中科院分区：
文献类型：
--
作者：
Liu, Jingjing;Wang, Chao;Liu, Zhuang
近年来，癌症联合治疗的发展受到越来越多的关注，其中许多依赖于纳米治疗诊断剂。在这项工作中，聚乙二醇（PEG）改性的介孔二氧化硅（MS）涂层的单壁碳纳米管（SWNTs）的制造和利用作为一个多功能的平台，成像引导联合治疗癌症。将模型化疗药物阿霉素（DOX）高效负载到所制备的SWNT@MS-PEG纳米载体的介孔结构中。在近红外（NIR）光下刺激后，在细胞内观察到光热触发的药物从DOX负载的SWNT@MS-PEG释放，导致协同的癌细胞杀伤作用。如通过光声（PA）和磁共振（MR）成像所揭示的，我们进一步揭示了静脉内注射到小鼠中后SWNT@MS-PEG/DOX的有效肿瘤积累。在小鼠肿瘤模型中进一步证明了使用该药剂的体内联合治疗，实现了显著的协同抗肿瘤作用，其上级优于通过单一治疗获得的协同抗肿瘤作用。我们的工作提出了一种新型的治疗诊断纳米平台，它可以高效地装载治疗分子，对外部近红外刺激做出响应，同时作为诊断成像剂。
The development of cancer combination therapies, many of which rely on nanoscale theranostic agents, has received increasing attention in recent years. In this work, polyethylene glycol (PEG) modified mesoporous silica (MS) coated single-walled carbon nanotubes (SWNTs) are fabricated and utilized as a multifunctional platform for imaging guided combination therapy of cancer. A model chemotherapy drug, doxorubicin (DOX), could be loaded into the mesoporous structure of the obtained SWNT@MS-PEG nano-carriers with high efficiency. Upon stimulation under near-infrared (NIR) light, photothermally triggered drug release from DOX loaded SWNT@MS-PEG is observed inside cells, resulting in a synergistic cancer cell killing effect. As revealed by both photoacoustic (PA) and magnetic resonance (MR) imaging, we further uncover efficient tumor accumulation of SWNT@MS-PEG/DOX after intravenous injection into mice. In vivo combination therapy using this agent is further demonstrated in a mouse tumor model, achieving a remarkable synergistic anti-tumor effect superior to that obtained by mono-therapy. Our work presents a new type of theranostic nano-platform, which could load therapeutic molecules with high efficiency, be responsive to external NIR stimulation, and at the same time serve as a diagnostic imaging agent.