Th1 and Th2 cells
Th1 and Th2 cells
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DOI：
10.1097/00062752-200101000-00009
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发表时间：
2001-01-01
影响因子：
3.2
通讯作者：
Flavell, RA
中科院分区：
文献类型：
--
作者：
Dong, C;Flavell, RA
激活后，CD4辅助性T （Th）细胞分化为Th1或Th2效应亚群。这两种类型的细胞产生不同的细胞因子，调节不同的免疫反应。本文综述了Th1和Th2细胞共刺激调控和趋化因子介导的归巢的不同特征的最新进展。讨论了在Th1和Th2细胞中选择性表达或激活以调节细胞因子基因表达的转录因子和信号通路。(C) 2001 Lippincott Williams & Wilkins公司
After activation, CD4 helper T (Th) cells differentiate into Th1 or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells. Transcription factors and signaling pathways that are selectively expressed or activated in Th1 and Th2 cells to regulate cytokine gene expression are discussed. (C) 2001 Lippincott Williams & Wilkins, Inc.