The epidermal growth factor receptor as a multifunctional allosteric protein.
The epidermal growth factor receptor as a multifunctional allosteric protein.
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DOI：
10.1021/bi00409a002
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发表时间：
1988-05
期刊：
影响因子：
2.9
通讯作者：
J. Schlessinger
中科院分区：
文献类型：
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作者：
J. Schlessinger
表皮生长因子是一种由53个氨基酸残基组成的多肽生长因子(Carpenter&Cohen，1979)，它通过结合并激活一种称为EGF受体的特异性细胞表面受体来介导其生物学反应。作为一种生长因子受体，EGF受体是独特的，因为它被三种不同的生长因子(EGF、转化生长因子-α和血管内皮生长因子)编码的不同的生长因子特异性地识别和激活。这些生长因子具有相似的二硫键骨架结构，但它们的总序列只有24%相同。然而，这三种生长因子都以相似的亲和力抑制彼此与EGF受体的结合，这表明它们与EGF受体的相似区域结合。
Ijpidermal growth factor (EGF) is a polypeptide growth factor of 53 amino acidresidues (Carpenter & Cohen, 1979), which mediates its biological responses by binding to and activating a specific cell surface receptor termed the EGF receptor. As a growth factor receptor, the EGF receptor is unique because it is specifically recognized and activated by three distinct growth factors encoded by separate genes (EGF, TGF-a, and VVGF). These growth factors have similar disulfide backbone structures, but their overall sequence is only 24% identical. Nevertheless, all three growth factors inhibit the binding of each other to the EGF receptor with similar affinities, suggesting that they bind to a similar region of the EGF receptor.