Growth-Inhibitory Effects of Artesunate, Pyrimethamine, and Pamaquine against Babesia equi and Babesia caballi in In Vitro Cultures
Growth-Inhibitory Effects of Artesunate, Pyrimethamine, and Pamaquine against Babesia equi and Babesia caballi in In Vitro Cultures
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DOI：
10.1128/aac.47.2.800-803.2003
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发表时间：
2003-02
影响因子：
4.9
通讯作者：
Akiko Nagai;N. Yokoyama;T. Matsuo;S. Bork;H. Hirata;X. Xuan;Yin-chang Zhu;F. Claveria;K. Fujisaki;I. Igarashi
中科院分区：
文献类型：
--
作者：
Akiko Nagai;N. Yokoyama;T. Matsuo;S. Bork;H. Hirata;X. Xuan;Yin-chang Zhu;F. Claveria;K. Fujisaki;I. Igarashi
摘要在体外培养条件下，研究了青蒿琥酯、乙胺嘧啶和扑马喹三种抗疟药对马巴贝虫和卡氏巴贝虫的生长抑制作用。B。马对乙胺嘧啶的抗性高于B。卡巴利。B。马对青蒿琥酯和帕马喹的敏感性也高于B。卡巴利。在这三种化合物中，乙胺嘧啶的体内有效性最有希望。
ABSTRACT Three antimalarial drugs, artesunate, pyrimethamine, and pamaquine, were evaluated for their growth-inhibitory effects against Babesia equi and Babesia caballi in in vitro culture. B. equi was more resistant to pyrimethamine than B. caballi. B. equi was also found to be more sensitive to artesunate and pamaquine than B. caballi. Of the three compounds, pyrimethamine gave the most promise for in vivo effectiveness.