An H5N1 highly pathogenic avian influenza virus that invaded Japan through waterfowl migration.
An H5N1 highly pathogenic avian influenza virus that invaded Japan through waterfowl migration.
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DOI：
10.14943/jjvr.59.2-3.89
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发表时间：
2011-08
期刊：
影响因子：
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通讯作者：
M. Kajihara;Keita Matsuno;E. Simulundu;M. Muramatsu;O. Noyori;Rashid Manzoor;E. Nakayama;Manabu Igarashi;Daisuke Tomabechi;R. Yoshida;M. Okamatsu;Y. Sakoda;Kimihito Ito;H. Kida;A. Takada
中科院分区：
文献类型：
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作者：
M. Kajihara;Keita Matsuno;E. Simulundu;M. Muramatsu;O. Noyori;Rashid Manzoor;E. Nakayama;Manabu Igarashi;Daisuke Tomabechi;R. Yoshida;M. Okamatsu;Y. Sakoda;Kimihito Ito;H. Kida;A. Takada
2010年，在日本最北部的北海道，从向南迁徙的看似健康的鸭子的粪便中分离到H5 N1高致病性禽流感病毒（HPAIV）。随后，在日本列岛水禽飞行路线对应的多个地点，在家禽和野生鸟类中检测到H5 N1高致病性禽流感病毒。北海道分离株与2009年和2010年春季蒙古天鹅中分离的H5 N1高致病性禽流感病毒在基因上几乎相同，但在实验感染鸭中的致病性低于2009年蒙古分离株。这些结果表明，在2009-2010年迁徙季节的水禽种群中可能选择和窝藏了致病性相对较弱的H5 N1高致病性禽流感病毒。我们的数据提供了“早期预警”信号，以备对前所未有的情况下，水禽水库作为永久的来源和传播者的HPAIV。
In 2010, an H5N1 highly pathogenic avian influenza virus (HPAIV) was isolated from feces of apparently healthy ducks migrating southward in Hokkaido, the northernmost prefecture of Japan. The H5N1 HPAIVs were subsequently detected in domestic and wild birds at multiple sites corresponding to the flyway of the waterfowl having stopovers in the Japanese archipelago. The Hokkaido isolate was genetically nearly identical to H5N1 HPAIVs isolated from swans in the spring of 2009 and 2010 in Mongolia, but less pathogenic in experimentally infected ducks than the 2009 Mongolian isolate. These findings suggest that H5N1 HPAIVs with relatively mild pathogenicity might be selected and harbored in the waterfowl population during the 2009-2010 migration seasons. Our data provide "early warning" signals for preparedness against the unprecedented situation in which the waterfowl reservoirs serve as perpetual sources and disseminators of HPAIVs.