Dual-Stimuli-Responsive, Polymer-Microsphere-Encapsulated CuS Nanoparticles for Magnetic Resonance Imaging Guided Synergistic Chemo-Photothermal Therapy
Dual-Stimuli-Responsive, Polymer-Microsphere-Encapsulated CuS Nanoparticles for Magnetic Resonance Imaging Guided Synergistic Chemo-Photothermal Therapy
复制标题
用于磁共振成像引导协同化学光热治疗的双刺激响应、聚合物微球封装的 CuS 纳米颗粒
DOI：
10.1021/acsbiomaterials.7b00204
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发表时间：
2017
影响因子：
5.8
通讯作者：
Li Penghui
中科院分区：
文献类型：
--
作者：
Zhang Li;Yang Zhe;Zhu Wei;Ye Zhilan;Yu Yiming;Xu Zushun;Ren Jinghua;Li Penghui
将生物医学成像和多模式治疗整合到一个平台中以增强抗癌疗效具有重要意义。本文中，通过无皂乳液聚合，在亲水性CuS NPs、苯乙烯（St）、N-异丙基丙烯酰胺（NIPAm）、甲基丙烯酸（MAA）和可聚合稀土配合物（Gd（AA）3 phen）的充分参与下，简单地制备了用于磁共振成像（MRI）引导的化学光热治疗的核/壳结构纳米治疗剂（CuS@共聚物）。该多功能微球具有良好的生物相容性，对盐酸阿霉素（DOX. HCl）的载药量高达15.3wt%，在低pH和高温下具有良好的释药性能。光敏CuS核可以同时有效地吸收近红外（NIR）光并将NIR光转化为致命的热，从而导致光热疗法（PTT）与化疗相结合的协同治疗效果。此外，附着在CuS纳米颗粒上的温度敏感性共聚物能够被热效应有效地感染，并产生高度可控的DOX释放。此外，CuS@共聚物/DOX显示出比单独的光热疗法或化学疗法增强的针对4 T1细胞的治疗功效。此外，药物递送过程可以通过体内MR图像可视化，并且纵向弛豫率（r1）计算为10.72 mM-1 s-1。这些结果表明CuS@共聚物微球在生物医学应用中具有高度吸引力的候选者。
Integrating biomedical imaging and multimodal therapies into one platform for enhanced anticancer efficacy is of great significance. Herein, a core/shell structured nanotheranostic (CuS@copolymer) for magnetic resonance imaging (MRI)-guided chemo-photothermal therapy was simply prepared via emulsifier-free emulsion polymerization with the full participation of hydrophilic CuS NPs, styrene (St),N-isopropylacrylamide (NIPAm), methacrylic acid (MAA), and polymerizable rare earth complex (Gd(AA)3phen). The synthesized multifunctional microspheres with excellent biocompatibility exhibited high loading capacity (15.3 wt %) for DOX·HCl and excellent drug release under low pH and high temperature. The photosensitive CuS cores which can simultaneously efficiently absorb near-infrared (NIR) light and convert NIR light to fatal heat, leading to a synergistic therapeutic effect combined photothermal therapy (PTT) with chemotherapy. Moreover, the temperature sensitive copolymer attached onto the CuS nanoparticles was able to be productively infected by the thermal effect and give rise to a highly controllable DOX release. Furthermore, the CuS@copolymer/DOX showed an enhanced therapeutic efficacy against 4T1 cells than separate photothermal therapy or chemotherapy. Additionally, the drug delivery procedure could be visualized by in vivo MR images and the longitudinal relaxivity (r1) was calculated to be 10.72 mM–1s–1. These results suggest the CuS@copolymer microspheres highly attractive candidates for biomedical applications.