Acoustoelasticity Analysis of Transient Waves for Non-Invasive In Vivo Assessment of Urinary Bladder.
Acoustoelasticity Analysis of Transient Waves for Non-Invasive In Vivo Assessment of Urinary Bladder.
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用于膀胱非侵入性体内评估的瞬态波声弹性分析。
DOI：
10.1038/s41598-018-38445-y
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发表时间：
2019
影响因子：
4.6
通讯作者：
Fatemi,Mostafa
中科院分区：
文献类型：
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作者：
Bayat,Mahdi;Adabi,Saba;Kumar,Viksit;Gregory,Adriana;Webb,Jeremy;Denis,Max;Kim,Baehyung;Singh,Aparna;Mynderse,Lance;Husmann,Douglas;Alizad,Azra;Fatemi,Mostafa
提出了一种非侵入性测量膀胱壁非线性弹性行为的方法。该方法是基于在不同的体积应变水平的膀胱组织模量的弹性变化的声弹性建模。在每个体积处，从实时超声图像获得组织应变。利用声辐射力在膀胱壁上激发瞬态兰姆波，并通过二维傅立叶分析得到瞬时剪切弹性模量。测量的弹性和应变数据，然后在声弹性公式中使用，以获得三阶弹性系数，称为非线性参数A，和初始静止弹性μ0。用福尔马林处理前后的活体猪膀胱样本（N = 9）对该方法进行了测试。估计的非线性参数A在处理样品中显著高于完整样品（p< 0.00062）。所提出的方法也适用于16例神经源性膀胱（10个顺应性和6个不顺应性的主题）。非依从性病例的估计非线性参数A显著高于依从性病例（p< 0.0293）。这些初步结果有望为膀胱组织非线性的非侵入性评价提供一种新的方法，可作为神经源性膀胱患者管理的新的诊断和预后生物标志物。
A non-invasive method for measurement of the bladder wall nonlinear elastic behavior is presented. The method is based on acoustoelasticity modeling of the elasticity changes in bladder tissue modulus at different volumetric strain levels. At each volume, tissue strain is obtained from the real-time ultrasound images. Using acoustic radiation force, a transient Lamb wave is excited on the bladder wall and instantaneous modulus of shear elasticity is obtained from the 2-D Fourier analysis of the spatial-temporal dispersion maps. Measured elasticity and strain data are then used in an acoustoelasticity formulation to obtain the third order elastic coefficient, referred to asnonlinearity parameter A, and initial resting elasticityμ0. The method was tested inex vivoporcine bladder samples (N = 9) before and after treatment with formalin. The estimated nonlinearity parameter,A, was significantly higher in the treated samples compared to intact (p< 0.00062). The proposed method was also applied on 16 patients with neurogenic bladders (10 compliant and 6 non-compliant subjects). The estimated nonlinearity parameterAwas significantly higher in the non-compliant cases compared to the compliant (p< 0.0293). These preliminary results promise a new method for non-invasive evaluation of the bladder tissue nonlinearity which may serve as a new diagnostic and prognostic biomarker for management of the patients with neurogenic bladders.