Impaired gap detection in juvenile microgyric rats
Impaired gap detection in juvenile microgyric rats
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DOI：
10.1016/j.devbrainres.2004.06.003
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发表时间：
2004-09-17
期刊：
影响因子：
--
通讯作者：
Fitch, RH
中科院分区：
文献类型：
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作者：
Peiffer, AM;Friedman, JT;Fitch, RH
先前对成年动物模型的研究将皮质神经迁移异常的存在联系起来（即，小脑回类似于在阅读障碍者的大脑中发现的），具有快速听觉处理（RAP）损伤。RAP损伤反过来发现在儿童与特定语言障碍（SLI），也在个人与诵读困难。间隙检测，一个简单的措施，听觉时间敏锐度，似乎是受损的儿童SLI，但不是在成人的睡眠障碍，即使这两组表现出受损的处理更复杂，快速的听觉任务。在目前的研究中，幼年大鼠双侧小脑回，但不是他们的成年同行，表现出受损的检测短期沉默的间隙在白色噪音相比，年龄匹配的假同窝出生。结果进一步支持：（1）神经迁移异常和RAP损伤之间的关联;（2）与人类语言障碍相关的RAP损伤动物模型的有效性。目前的结果也支持这样的观点，即与皮层畸形相关的听觉处理障碍可能在发育早期以相对“低”的水平（例如，简单的间隙检测），但是可能需要“高阶”听觉辨别任务（例如，声调序列，音素辨别）在以后的生活中被引出。(C)2004 Elsevier B. V.保留所有权利。
Previous research with adult animal models links the presence of cortical neuromigrational anomalies (i.e., microgyria similar to that found in brains of dyslexics) with rapid auditory processing (RAP) impairments. RAP impairments are in turn found in children with specific language impairment (SLI) and also in individuals with dyslexia. Gap detection, a simple measure of auditory temporal acuity, appears to be impaired in children with SLI but not in dyslexic adults, even though both groups exhibit impaired processing on more complex, rapid auditory tasks. In the current study, juvenile rats with bilateral microgyria, but not their adult counterparts, exhibited impaired detection of short duration silent gaps in white noise when compared to age-matched sham littermates. Results lend further support to: (1) an association between neuromigrational anomalies and RAP impairments; and (2) the validity of an animal model of RAP impairments associated with language disturbances in humans. Current results also support the view that auditory processing disturbances associated with cortical malformations may be evident early in development at a relatively "low" level (e.g., simple gap detection), but may require "higher-order" auditory discrimination tasks (e.g., tone sequences, phonemic discriminations) to be elicited later in life. (C) 2004 Elsevier B.V. All rights reserved.