QUANTITATIVE GROWTH AND DEVELOPMENT OF HUMAN BRAIN
QUANTITATIVE GROWTH AND DEVELOPMENT OF HUMAN BRAIN
复制标题
DOI：
10.1136/adc.48.10.757
复制
发表时间：
1973-01-01
影响因子：
5.2
通讯作者：
SANDS, J
中科院分区：
文献类型：
--
作者：
DOBBING, J;SANDS, J
本文分析了139例从孕10周到生后7年的完整人脑和9例成人脑，以定量描述人脑的生长突增。对三个主要区域的重量、DNA、胆固醇和水含量进行了检查。生长突增期比以前所认为的要晚得多。小脑具有特殊的生长特征，并且在妊娠10 ~ 18周有一个单独的时期，此时成年神经元细胞的数量可能在很大程度上达到。这些研究结果的脆弱性发育中的大脑的影响进行了讨论。
One hundred and thirty-nine complete human brains ranging in age from 10 weeks' gestation to 7 postnatal years, together with 9 adult brains, have been analysed in order to describe the human brain growth spurt quantitatively. The three major regions were examined for weight, DNA, cholesterol, and water content. The growth spurt period is much more postnatal than has formerly been supposed. The cerebellum has special growth characteristics; and there is a separate period from 10 to 18 weeks' gestation when adult neuronal cell number may largely be achieved. The implications of these findings for the vulnerability of developing brain are discussed.