Microglia rely on SYK signalling to mount neuroprotective responses in models of Alzheimer's disease and multiple sclerosis.
Microglia rely on SYK signalling to mount neuroprotective responses in models of Alzheimer's disease and multiple sclerosis.
复制标题
DOI：
10.1002/ctm2.1178
复制
发表时间：
2023-01
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
--
作者：
在经历了一代失败的治疗后，小胶质细胞吸引了科学家们寻找尚未探索的治疗神经退行性疾病的途径。过去十年的研究揭示了小胶质细胞通过这些脑驻留免疫细胞与疾病病理和大脑中其他疾病相关细胞类型的相互作用改变神经退行性变轨迹的显着能力。从这些集体工作中产生的想法是，小胶质细胞在神经疾病的发病机制中既可以发挥神经保护作用，也可以发挥有害作用。然而，小胶质细胞获得有害和有益功能的原因仍然是该领域存在很大争议的问题。尽管如此，最近的进展已经开始揭示一些主要的转录网络和效应机制，这些转录网络和效应机制支持小胶质细胞影响神经退行性疾病的易感性和进展。揭示小胶质细胞改变阿尔茨海默病（AD）和多发性硬化症（MS）等神经退行性疾病病理的过程
After a generation of failed therapies, microglia have captivated scientists searching for unexplored avenues to treat neurodegenerative diseases. The last decade of research has unveiled a remarkable capacity for microglia to alter the trajectory of neurodegeneration through the interaction of these brain-resident immune cells with disease pathology and other disease-associated cell types in the brain. Emerging from this collective work is the idea that microglia can play both neuroprotective and deleterious roles in neurological disease pathogenesis. However, what accounts for the acquisition of damaging versus beneficial functions by microglia is still a matter of great debate in the field. Despite this, recent advances have begun to uncover some of the major transcriptional networks and effector mechanisms that underpin the ability of microglia to impact neurodegenerative disease susceptibility and progression. Unearthing the processes by which microglia can modify pathology in neurodegenerative diseases such as Alzheimer’s disease (AD) and multiple sclerosis (MS)
登录
查看更多内容
影响因子：
4.6
作者：
Kim SM;Mun BR;Lee SJ;Joh Y;Lee HY;Ji KY;Choi HR;Lee EH;Kim EM;Jang JH;Song HW;Mook-Jung I;Choi WS;Kang HS
通讯作者：
Kang HS
影响因子：
64.5
作者：
Keren-Shaul, Hadas;Spinrad, Amit;Amit, Ido
通讯作者：
Amit, Ido
影响因子：
64.8
作者：
Pluvinage, John V.;Haney, Michael S.;Wyss-Coray, Tony
通讯作者：
Wyss-Coray, Tony
影响因子：
16.2
作者：
Griciuc A;Serrano-Pozo A;Parrado AR;Lesinski AN;Asselin CN;Mullin K;Hooli B;Choi SH;Hyman BT;Tanzi RE
通讯作者：
Tanzi RE
影响因子：
64.5
作者：
Ennerfelt, Hannah;Frost, Elizabeth L.;Shapiro, Daniel A.;Holliday, Coco;Zengeler, Kristine E.;Voithofer, Gabrielle;Bolte, Ashley C.;Lammert, Catherine R.;Kulas, Joshua A.;Ulland, Tyler K.;Lukens, John R.
通讯作者：
Lukens, John R.