Pace and stability of embryonic development affect telomere dynamics: an experimental study in a precocial bird model
Pace and stability of embryonic development affect telomere dynamics: an experimental study in a precocial bird model
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胚胎发育的速度和稳定性影响端粒动力学：早熟鸟类模型的实验研究
DOI：
10.1098/rspb.2020.1378
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
P. Monaghan
中科院分区：
文献类型：
--
作者：
A. Stier;N. Metcalfe;P. Monaghan
人们越来越认识到，产前对端粒长度的影响是健康和成人疾病发育起源的潜在因素。虽然端粒长度受产前条件的影响已变得越来越清楚，但对胚胎发生过程中影响端粒动态的因素仍知之甚少。我们通过改变日本鹌鹑的孵化温度及其稳定性来控制胚胎发育的速度和稳定性。我们研究了从胚胎发生到成年对端粒动态的影响，以及端粒缩短的三个潜在驱动因素、生长速度、氧化损伤和产前糖皮质激素水平。在胚胎发生的前 75% 中，端粒长度并未受到我们的产前操作的影响，但在经历更快（即高温）或不太稳定的胚胎发育的群体中，端粒长度在孵化时会缩短。这些生命早期端粒长度的差异一直持续到成年。发育不稳定对孵化时端粒长度的影响可能是由发育过程中糖皮质激素分泌增加介导的。胚胎发育的速度和稳定性似乎都是决定端粒长度和成年期动态的关键因素，快速且不稳定的发育导致端粒较短，并可能导致寿命缩短等不良相关结果。
Prenatal effects on telomere length are increasingly recognized as a potential contributor to the developmental origin of health and adult disease. While it is becoming clear that telomere length is influenced by prenatal conditions, the factors affecting telomere dynamics during embryogenesis remain poorly understood. We manipulated both the pace and stability of embryonic development through varying incubation temperature and its stability in Japanese quail. We investigated the impact on telomere dynamics from embryogenesis to adulthood, together with three potential drivers of telomere shortening, growth rate, oxidative damage and prenatal glucocorticoid levels. Telomere length was not affected by our prenatal manipulation for the first 75% of embryogenesis, but was reduced at hatching in groups experiencing faster (i.e. high temperature) or less stable embryonic development. These early life differences in telomere length persisted until adulthood. The effect of developmental instability on telomere length at hatching was potentially mediated by an increased secretion of glucocorticoid hormones during development. Both the pace and the stability of embryo development appear to be key factors determining telomere length and dynamics into adulthood, with fast and less stable development leading to shorter telomeres, with the potential for adverse associated outcomes in terms of reduced longevity.
影响因子：
6.6
作者：
Stoffel, Martin A.;Nakagawa, Shinichi;Schielzeth, Holger
通讯作者：
Schielzeth, Holger
DOI：
10.1073/pnas.1113306109
发表时间：
2012-01-31
影响因子：
11.1
作者：
Heidinger, Britt J.;Blount, Jonathan D.;Monaghan, Pat
通讯作者：
Monaghan, Pat